Aprotinin 9087-70

Aprotinin yog dab tsi?

Aprotinin 9087-70yog ib qho serine protease inhibitor muab rho tawm los ntawm cov ntaub so ntswg tsiaj. Trypsin, plasmin, thrombin, kallikrein, thiab lwm yam plasma proteases, nrog rau cov ntshav txhaws, txhua tus tuaj yeem cuam tshuam los ntawm nws. Ntxiv nrog rau kev tiv thaiv cov kab mob fibrinolytic los ntawm kev ua haujlwm,Aprotinin hmoovkuj tiv thaiv platelet aggregation. Tsis tas li ntawd, nws txo qis kev noj ntawm cov khoom sib txuam los ntawm kev thaiv txoj hauv kev coagulation. Hauv ntau dua 50% ntawm cov txheej txheem tseem ceeb, nws txo qis kev phais los ntshav thiab feem ntau tshem tawm qhov xav tau ntawm cov ntshav. Cov hmoov dawb rau me ntsis daj ua cov khoom. Nws yog insoluble nyob rau hauv ethanol, acetone, los yog ether tab sis soluble nyob rau hauv physiological saline los yog dej.

Aprotinin yog ib qho protease inhibitor nrog keeb kwm kev loj hlob txij thaum xyoo 1950s. Nov yog cov ntsiab lus luv luv ntawm keeb kwm kev loj hlob ntawm Aprotinin hmoov:

1952: Cov qauv ntxov tshaj plaws ntawm Aprotinin raug cais tawm ntawm lub ntsws bovine los ntawm Swedish kws tshawb fawb Karl Kallikrein thiab Herman Kalz. Lawv hu ua qhov no protease inhibitor Trasylol.

1963: Trasylol tau ua tiav siv hauv kev phais plawv, dhau los ua tus thawj protease inhibitor siv rau kev phais hemostasis.

1993: Tom qab kev pom zoo los ntawm US Food and Drug Administration (FDA), Bayer pib muag Trasylol hauv Asmeskas kev ua lag luam.

2006: Aprotinin hmoov tau siv dav thoob plaws ntiaj teb los ua tus kws phais hemostatic, tshwj xeeb hauv kev phais plawv.

2008: Ib qho kev sim tshuaj hu ua BART txoj kev tshawb nrhiav pom tias kev siv Trasylol tuaj yeem ua rau muaj kev tuag ntau dua piv rau lwm cov tshuaj hemostatic. Raws li cov lus teb, Bayer tau txiav txim siab ncua kev muag khoom thoob ntiaj teb ntawm Trasylol thiab ua kev tshawb fawb ntxiv.

2011: Tom qab rov ntsuam xyuas thiab kev tshawb fawb, FDA pom zoo kom rov pib siv Trasylol nrog kev txwv kev siv thiab ceeb toom.

Txawm li cas los xij, vim muaj kev txhawj xeeb txog kev nyab xeeb, kev siv Aprotinin hmoov tau txwv hauv kev lag luam thoob ntiaj teb thiab tau maj mam hloov los ntawm lwm cov tshuaj hemostatic. Tam sim no, Aprotinin tseem siv nyob rau hauv cov xwm txheej tshwj xeeb hauv qee lub tebchaws thiab cheeb tsam, tab sis nws txoj kev siv tau txo qis.

Cov ntaub ntawv tseem ceeb:

Khoom npe: Aprotinin

Lwm lub npe: APT; TRYPSIN INHIBITOR, PANCREAS HOM; TRYPSIN INHIBITOR (BASIC); TRYPSIN INHIBITOR, BOVINE LUNG

CAS:9087-70-1

MF: C284H432N84O78R2S7

MW: 6495.43988

EINECS:232-994-9

MDL No.: MFCD00130541

Kev Ua Haujlwm (anhydrous hauv paus): Ntau dua lossis sib npaug rau 3.0EPU/mg

cia temp. 2-8 degree , Khaws rau hauv nruj, lub teeb-resistant ntim.

Stability: ruaj khov

Tus qauv qauv:

Cov qauv zoo

Hom phiaj

Kev tshawb fawb hauv vitro

Aprotinin 9087-70yog ib qho me me molecule inhibitor ntawm fibrinolysis uas inhibits trypsin thiab lwm yam proteinases. Hauv cell biology, nws yog siv los ua protease inhibitor los tiv thaiv cov protein degradation thaum cov ntaub so ntswg homogenization thiab cell lysis. Aprotinin inhibits fibrinolytic kev ua si nyob rau hauv ib tug npaum li cas ntawm koob tshuaj thiab prolongs lub sij hawm los ntshav. Hauv vitro, nws yog ib qho zoo inhibitor ntawm intrinsic coagulation txoj kev.

Hauv vivo kev tshawb fawb:

Aprotinin inhibits clot lysis nyob rau hauv vitro, prolongs Tail los ntshav lub sij hawm nyob rau hauv nas, thiab prolongs lub sij hawm clotting nyob rau hauv tib neeg plasma. Hauv cov qauv nas venous shunt, aprotinin txo qhov hnyav ntawm thrombus.

Txoj kev tsim khoom:

Fresh los yog khov bovine ntsws yog minced thiab muab rho tawm nrog dej, ua raws li los ntawm ammonium sulfate nag lossis daus. Lub precipitate yog kho nrog trichloroacetic acid kom tshem tawm impurities, thiab tom qab ntawd raug rau ntau kauj ruam nrog rau kev lim ntshav, desalting, thiab nag lossis daus kom tau aprotinin. Tag nrho cov txiaj ntsig yog kwv yees li 23%.

Function & Application

Muaj nuj nqi:

Aprotinin lub luag haujlwm tseem ceeb yog ua raws li cov molecule inhibitor ntawm fibrinolysis, inhibiting pancreatic proteases thiab lwm yam protein hydrolyzing enzymes. Ntxiv rau qhov no, Aprotinin tseem muaj cov haujlwm hauv qab no:

• Txo cov ntshav los ntshav: nws yog ib qho zoo hemostatic tus neeg sawv cev uas tuaj yeem txo cov ntshav poob thaum phais thiab txhim kho kev phais kom zoo.
• Tiv thaiv lub cev los ntawm ischemia-reperfusion raug mob: nws tuaj yeem tiv thaiv cov kabmob tseem ceeb xws li lub plawv, lub ntsws, thiab daim siab ntawm ischemia-reperfusion raug mob los ntawm inhibiting inflammatory reactions thiab platelet activation.
• Anti-inflammatory teebmeem: nws muaj peev xwm alleviate inflammatory teb thiab txo zus tau tej cov inflammatory mediators, yog li muab ib tug kho nyhuv rau inflammatory kab mob.
• Kev kho tus mob pancreatitis: nws tuaj yeem txo qis kev tuag ntawm cov neeg mob uas mob pancreatitis thiab txo cov tsos mob thiab cov teeb meem cuam tshuam nrog tus mob.

Daim ntawv thov

Cov kev siv tseem ceeb ntawm Aprotinin muaj xws li:

• Hemostasis thaum lub sij hawm kev phais loj: nws feem ntau yog siv los ua tus neeg sawv cev hemostatic, tshwj xeeb tshaj yog nyob rau hauv cov kev phais loj xws li mob plawv thiab pulmonary cov txheej txheem.
• Kev hloov pauv hauv lub cev xws li lub siab thiab lub plawv hloov pauv: nws tuaj yeem tiv thaiv cov kabmob ntawm ischemia-reperfusion raug mob thaum hloov pauv.
• Kev kho mob ntawm tus mob pancreatitis: nws tuaj yeem txo qis kev tuag ntawm cov neeg mob uas mob pancreatitis.
• Kev kho mob ntawm cov kab mob inflammatory: nws muaj qee yam kev kho mob ntawm cov kab mob inflammatory.

Ntim:

Shipping:

Cov neeg siv khoom tawm tswv yim

Xi'an Yihui daim ntawv pov thawj

Xi'an Yihui tuam txhab muaj cov hauv qab no zoo:

Kev ruaj ntseg zoo: peb siv high-purity lead-free ntau lawm tshuab. Cov khoom tau dhau los ua ntau yam kev tsim khoom nruj thiab cov txheej txheem kuaj xyuas kom paub meej cov khoom zoo.

Tus nqi tsim nyog: peb muaj tus nqi tsim nyog piv rau cov khoom zoo sib xws.

Cov kev pabcuam zoo tshaj plaws: peb muaj cov kws tshaj lij kev pabcuam thiab pab pawg pabcuam tomqab muag, yog li peb tuaj yeem muab kev pabcuam kev tshaj lij thiab kev pabcuam tomqab muag los xyuas kom cov neeg siv khoom tau txais kev paub zoo tshaj plaws.

Unified hom duab: peb txais kev sib koom ua ke lub logo thiab tsim qauv ntawm cov khoom ntim, ua kom yooj yim rau cov neeg siv khoom kom paub txog lub hom phiaj thiab txhim kho lub hom lag luam.

Xi 'an Yihui tuam txhab muag khoom, khoom siv ntau lawm

Xi'an Yihui tuam txhab muaj qib siab ntawm kev tshawb fawb thiab kev txhim kho muaj peev xwm

Xi'an Yihui Lub Tuam Txhab Advanced ntau lawm cov cuab yeej thiab thev naus laus zis

Zoo meej kev pab cuam tom qab muag

Hauv kev xaus, raws li tus kws tshaj lijAprotinin 9087-70chaw tsim tshuaj paus, peb muaj advanced technology, scale kom zoo dua, qhov zoo tshaj plaws zoo, nplua nuj ntau lawm kev, thiab cov kev pab zoo heev. Cov txiaj ntsig zoo no yuav ua rau pebAprotinin hmoovsawv tawm hauv kev sib tw ua lag luam thiab yeej ntau tus neeg siv khoom ntseeg siab thiab kev txhawb nqa. yog koj xav tauAprotinin, pls xav tias dawb hu rau peb txhua lub sijhawm. peb yuav teb koj asap.

peb cov ntaub ntawv tiv tauj:

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