Vitamin K2 (MK-4) CAS 863-61-6

Vitamin K2 (MK-4) yog dab tsi CAS 863-61-6?

Vitamin K2 (MK-4) CAS 863-61-6yog ib tug daj crystalline compound tau los ntawm acetone-ethanol los yog methanol-chloroform, nrog ib tug molecular luj ntawm 580.90 thiab ib tug melting point ntawm 51-52 degree . Nws yog insoluble nyob rau hauv dej, me ntsis soluble nyob rau hauv roj, thiab soluble nyob rau hauv organic solvents xws li ethanol, ether, acetone, benzene, thiab chloroform. Txawm li cas los xij, nws cov solubility qis dua li cov vitamin K1. Nws undergoes decomposition nyob rau hauv muaj zog acids, oxidizing agents, alkaline tej yam kev mob, thiab lub teeb raug.Vitamin K yog ib pawg ntawm cov tebchaw nrog quinone lug, nrog rau tsib sib txawv tebchaw hu ua vitamin K1, K2, K3, K4, thiab K5. Vitamin K2 yog ib tug series ntawm cov tebchaw uas yog daj ntseg crystals thiab yog mas synthesized los ntawm txoj hnyuv kab mob. Muaj 14 yam sib txawv ntawm cov vitamin K2 raws li qhov ntev ntawm sab saw ntawm C3 isoprenyl pawg.Vitamin K2 (MK-4), kuj hu uaMenatetrenone, feem ntau yog siv los kho osteoporosis. Kev tshawb fawb tau pom tias menaquinone-4 muaj cov khoom osteogenic, txhawb cov calcium metabolism, thiab inhibits pob txha resorption los ntawm osteoclasts, yog li ua rau pob txha ceev thiab tiv thaiv / kho pob txha. Menaquinone-4 yog ib yam khoom oily thiab nws yooj yim rau decomposition thaum raug lub teeb, uas ua rau nws haum rau formulation mus rau hauv mos capsules.Menaquinone-4 (Vitamin K2) yog dav pom nyob rau hauv nplooj ntsuab nplooj thiab zaub, as well as ntses, nqaij, cheese, thiab cod siab roj. Nws tuaj yeem muab rho tawm los ntawm cov nplooj nettle thiab cov nqaij ntses decomposed, los yog synthesized siv 2-methylnaphthoquinone-1,4 ua cov khoom pib.

Cov ntaub ntawv tseem ceeb:

Khoom npe: Vitamin K2 (MK-4); Menatetrenone

CAS:863-61-6

MF: C31H40O2

MW: 444.65

Melting point: 350 degree

cia kub: -20 degree

Tsos: Yellow crystal hmoov

Stability: ruaj khov rau 2 xyoos

Tus qauv qauv:

Cov qauv zoo:

Physiological ua

Vitamin K2 (MK-4) CAS 863-61-6, tseem hu ua Menaquinone -4, yog ib qho tshuaj vitamin tshwm sim uas muaj cov qauv ntawm naphthoquinone thiab nthuav tawm cov khoom tiv thaiv hemorrhagic. Xyoo 1929, Dam nrhiav tau ob hom vitamin K hauv qhov xwm txheej, uas yog K1 thiab K2, ob qho tib si yog cov tshuaj naphthoquinone. Menaquinone-4 zoo nkaus li cov muaju daj lossis cov kua roj, tsis muaj dej, soluble hauv cov kuab tshuaj organic thiab cov roj cog, cov cua sov ruaj khov tab sis muaj kev cuam tshuam rau kev degradation los ntawm lub teeb. Nws ua lub luag haujlwm hauv kev txhawb nqa cov synthesis ntawm prothrombin hauv lub siab thiab tswj cov synthesis ntawm clotting yam VII, IX, thiab X, yog li ua kom cov ntshav txhaws. Tsis tas li ntawd, nws plays lub luag haujlwm tseem ceeb hauv intracellular qabzib phosphorylation. Hauv qee cov kab mob, xws li Bacillus subtilis, nws yog ib feem ntawm cov kab mob ua pa. Kev tsis txaus hauv menaquinone-4 ua rau lub sijhawm ua kom lub cev ntev, ua rau cov ntshav ntau dhau thaum muaj kev raug mob. Txij li thaum nws tuaj yeem ua ke los ntawm cov kab mob hauv tib neeg thiab tsiaj cov hnyuv, qhov tsis txaus yog feem ntau tsawg.

Mechanism ntawm Action

Cov txheej txheem ntawm kev ua ntawm Menaquinone-4 (Vitamin K2) suav nrog cov hauv qab no:

• Hemostatic muaj nuj nqi: Vitamin K2 txhawb cov synthesis ntawm prothrombin nyob rau hauv daim siab thiab tswj cov synthesis ntawm clotting yam VII, IX, thiab X. Cov kab mob no ua lub luag haujlwm tseem ceeb hauv cov txheej txheem ntshav coagulation, thiab muaj vitamin K2 tso cai rau cov ntshav txhaws. sai, yog li tso tseg los ntshav.
• Cov pob txha metabolism ua haujlwm: Vitamin K2 muaj kev tswj xyuas cov pob txha metabolism. Nws nce pob txha ceev thiab tiv thaiv osteoporosis los ntawm kev txhawb kev tsim thiab ua kom cov pob txha hlwb. Vitamin K2 kuj inhibits kev ua ntawm osteoclasts thiab txo cov pob txha puas.
• Cellular signaling muaj nuj nqi: Vitamin K2 plays lub luag hauj lwm tseem ceeb nyob rau hauv intracellular qabzib phosphorylation thiab koom nyob rau hauv intracellular teeb liab transduction txheej txheem.
• Cov kab mob ua pa ua pa: Hauv qee cov kab mob, xws li Bacillus subtilis, Vitamin K2 tuaj yeem ua haujlwm ua ib feem ntawm cov kab mob ua pa, koom nrog cov kab mob tsim tawm.

Hauv cov ntsiab lus, Vitamin K2 plays lub luag haujlwm tseem ceeb hauv lub cev los ntawm ntau lub tswv yim xws li tswj cov ntshav coagulation, cov pob txha metabolism, hloov cov teeb liab ntawm tes, thiab koom nrog hauv cov kab mob ua pa. Nws qib ib txwm nyob hauv tib neeg lub cev yog qhov tseem ceeb rau kev tswj hwm hemostasis sib npaug, pob txha noj qab haus huv, thiab kev ua haujlwm ntawm tes.

Kev mob tshwm sim

Qee zaum, Menaquinone-4 (Vitamin K2) tuaj yeem ua rau tsis xis nyob hauv plab, xeev siab, ntuav, raws plab, mob plab, thiab plab zom mov. Qee zaum, pob khaus, tawv nqaij liab, khaus, thiab mob taub hau tuaj yeem tshwm sim. Cov qib siab ntawm daim siab enzymes xws li GOT, GPT, -GTP, thiab BUN kuj yuav raug soj ntsuam.

Cov tsos mob tsis txaus

Tib neeg ib txwm muaj cov theem txaus ntawm Menaquinone-4 (Vitamin K2) vim nws cov kab mob hauv plab hnyuv. Txawm li cas los xij, qhov tsis txaus tuaj yeem tshwm sim thaum siv cov tshuaj sulfa ntev lossis tshuaj tua kab mob uas ua rau cov kab mob ua haujlwm tsis zoo, lossis hauv cov xwm txheej uas cuam tshuam lipid absorption xws li bile duct obstruction, steatorrhea, tropical diarrhea, lossis pancreatic dysfunction. Nyob rau hauv tas li ntawd, vitamin K deficiency yuav tshwm sim. Txawm tias kev raug mob me me uas tsis muaj kev phom sij nyob rau hauv ib txwm muaj tshwm sim tuaj yeem ua rau tsis tuaj yeem los ntshav thiab tuag rau cov tib neeg uas tsis muaj vitamin K. Yog li ntawd, cov neeg mob plab hnyuv los yog cov kab mob hauv lub cev yuav tsum tau txhaj tshuaj vitamin K ua ntej kev phais. Cov menyuam mos yug tshiab, uas nws lub plab hnyuv tsis muaj menyuam, kuj tseem tuaj yeem muaj cov vitamin K tsis txaus los ntshav, uas txuas ntxiv mus txog rau lub plab hnyuv los ntawm cov kab mob. Kev tswj hwm ntawm vitamin K rau cov poj niam cev xeeb tub ua ntej yug menyuam tuaj yeem tiv thaiv tus mob no. Txawm li cas los xij, yog tias cov vitamin K raug txhaj ncaj qha rau hauv tus menyuam mos, ntau npaum li cas yuav tsum tau zam kom tsis txhob muaj hyperbilirubinemia thiab jaundice. Hauv cov neeg laus, ntev npaum li kev nqus rog hauv cov hnyuv yog qhov qub, tsis muaj kev pheej hmoo ntawm vitamin K tsis txaus. Cov neeg mob uas paub vitamin K tsis muaj peev xwm pom tau tias txo qis ntawm prothrombin nyob rau hauv cov ntshav thiab lub sij hawm ntev ntawm cov ntshav txhaws. Yog li, lub luag haujlwm tseem ceeb ntawm Vitamin K ntseeg tau tias yog kev txhawb nqa ntawm prothrombin synthesis hauv daim siab. Tom qab xyoo ntawm kev tshawb fawb, nws tau pom tias vitamin K kuj plays lub luag hauj lwm nyob rau hauv lub synthesis ntawm coagulation yam VII, IX, X, thiab lwm yam nyob rau hauv lub siab. Thaum tsis muaj vitamin K, cov theem ntawm cov coagulation yam hauv cov ntshav txo. Vim li no, thaum muaj mob qog noj ntshav lossis mob cirrhosis uas muaj kev puas tsuaj loj thiab ua haujlwm tsis zoo ntawm daim siab ua haujlwm, kev tswj hwm ntawm Vitamin K tsis zoo.

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