5-Azacytidine hmoov

5-Azacytidine yog dab tsi?

5-Azacytidine hmoov,tseem hu ua Azacitidine los yog 5-AC, yog ib yam tshuaj. Nws yog ib qho nucleoside analog ua los ntawm adenine puag thiab lub nplhaib-puab molecule hu ua nitrogen heterocycle uas muaj nitrogen. Nws yog DNA methyltransferase inhibitor thiab nquag siv los kho myelodysplastic syndrome (MDS), mob ntshav.Nws lub npe tshuaj yog 4-Amino-1-(-D-ribofuranosyl)-1,3 ,5-triazin-2(1H)-ib, thiab nws tus lej CAS yog320-67-2. Nws cov qauv tshuaj yog C8H12N4O5, thiab nws qhov hnyav molecular yog 244.2 g / mol. Nws tuaj yeem hloov pauv cov noob qhia thiab muaj cov txiaj ntsig kho mob hauv cov xwm txheej zoo li myelodysplastic syndrome (MDS) los ntawm kev cuam tshuam nrog DNA methylation txheej txheem. Los ntawm kev tiv thaiv DNA methylation hloov, nws txhawb txoj kev loj hlob ntawm cov hlwb hematopoietic noj qab haus huv thiab thim rov qab tsim cov hlwb hematopoietic.

Keeb kwm ntawm 5-Azacytidine qhov kev tshawb pom tau rov qab mus rau xyoo 1950. Lub ntsiab lus ntawm nws qhov kev tshawb nrhiav tuaj yeem pom ntawm no:

Thawj5-Azacytidine APIsynthesis tau ua tiav nyob rau xyoo 1958 los ntawm cov kws tshawb fawb los ntawm Chemical Development Section ntawm National Institutes of Health hauv Tebchaws Meskas. Lawv pom tias cov tshuaj no inhibits methylation ntawm cellular DNA.

Lub koom haum National Cancer (NCI) hauv Tebchaws Meskas tau pib tshawb fawb ntxiv txog azacytidine hauv xyoo 1964.

Azacytidine tau txais kev tshawb fawb ntxiv thiab kev txhim kho thoob plaws lub xyoo tom ntej. Lub US Food and Drug Administration (FDA) tau tso cai rau Azacytidine (tseem ua lag luam raws li Vidaza) kev pom zoo hauv xyoo 1985 rau kev tswj hwm cov kev pheej hmoo siab myelodysplastic syndrome (MDS). Yog li ntawd, nws tau nquag siv los kho MDS thiab.

Cov ntaub ntawv tseem ceeb:

Lub npe khoom: 5-Azacytidine
CAS: 320-67-2
MF: C8H12N4O5
MW: 244.2
EINECS:206-280-2
MDL No.: MFCD00006539
Purity: 99 feem pua
Stability: ruaj khov rau 2 xyoos
Solubility: Soluble hauv DMSO (txog 25 mg / ml), lossis hauv dej (txog 12 mg / ml).
Daim Ntawv Thov: Qib Tshuaj lossis siv rau kev tshawb fawb.
Packing: Raws li koj qhov kev thov
Cia: Chav Temp.
Tus qauv qauv:

Cov qauv zoo:

Function thiabdaim ntawv thov:

Cov hauv qab no yog cov kev siv tseem ceeb rau5-Azacytidine hmoovthiab nws thaj chaw siv:

Inhibition ntawm cell loj hlob thiab proliferation: 5-Azacytidine, ib tug DNA methyltransferase inhibitor, tiv thaiv cov noob caj noob ces thiab suppresses cell loj hlob thiab proliferation los ntawm cuam tshuam nrog DNA methylation hauv hlwb.

Myelodysplastic syndromes (MDS) yog ib chav kawm ntawm cov kab mob clonal cuam tshuam rau hematopoietic qia hlwb uas yog tus cwj pwm los ntawm qhov tsis xws luag hauv pob txha pob txha hematopoiesis. Cov neeg mob MDS uas muaj kev pheej hmoo siab feem ntau tau kho nrog 5-azacytidine txhawm rau txhim kho cov ntshav tsis zoo, ua kom lub neej ntev ntawm tus neeg mob, thiab kho cov kab mob hematopoietic li qub thiab kev loj hlob.

Kev kho mob ntev myelomonocytic leukemia (CMML): CMML yog ib qho myeloproliferative neoplasm cim los ntawm kev nce hauv granulocytes thiab monocytes hauv cov ntshav peripheral. 5-Azacytidine tuaj yeem siv los kho CMML txhawm rau txo qis ntawm cov hlwb tsis zoo, txwv cov cell proliferation, thiab nce tus neeg mob ciaj sia.

Kev kho mob ntawm cov kab mob hematological ntxiv: 5-Azacytidine kuj tseem siv los kho lwm cov kab mob hematological xws li mob myeloid leukemia (AML) thiab mob qog ntshav qog ntshav qog ntshav (CLL), ntxiv rau MDS thiab CMML. Nws pab tswj kev loj hlob ntawm tes tsis txaus ntseeg, tswj hwm hematopoietic muaj nuj nqi, thiab txhim kho tus neeg mob lub neej zoo thiab kev kwv yees.

Nws yog ib qho tseem ceeb kom nco ntsoov tias 5-Azacytidine yog ib qho tshuaj muaj zog thiab tsuas yog yuav tsum tau siv raws li kws kho mob saib xyuas. Qhov koob tshuaj thiab lub sijhawm yuav tsum raug xaiv nyob ntawm tus neeg mob tus neeg mob.

Stability thiab cia:

Vim nws qhov ruaj khov tsis muaj zog, 5-azacytidine tau tawg sai sai los ntawm lub teeb, cua sov, thiab noo noo. Nws raug nquahu kom khaws cia rau hauv cov xwm txheej hauv qab no kom tswj tau nws qhov zoo thiab ua haujlwm tau zoo:

Kub: Nws raug nquahu kom khaws 5-Azacytidine hauv lub tub yees ntawm qhov kub ntawm 2 txog 8 degrees Celsius (36 txog 46 degrees Fahrenheit). Tsis txhob raug kub hnyiab thiab ua haujlwm kom koj lub cev ntawm qhov kub thiab txias tsis tu ncua.

Lub teeb: Nws yuav tsum tau khaws cia tawm ntawm lub teeb muaj zog thiab ncaj qha tshav ntuj thiab khaws cia rau hauv qhov chaw tiv thaiv lub teeb. Txhawm rau kom tsis txhob muaj teeb pom kev zoo, npog nws hauv aluminium ntawv ci lossis siv opaque cia ntim.

Humidity: Lub chaw cia khoom yuav tsum tau qhuav kom tsis txhob muaj kev puas tsuaj los ntawm noo noo. Txhawm rau kom tsis txhob muaj tshuaj lom lossis tsis zoo, nyob deb ntawm qhov chaw ntub dej.

Thov ua raws li kev ceev faj txog kev nyab xeeb hauv qab no:

Txhawm rau tiv thaiv cov tshuaj los ntawm kev degrading, zam kev hloov pauv sai sai thiab kev vibrations.

Tshuaj xyuas cov tsos mob thiab daim ntawv lo ua ntej siv. Yog tias koj pom ib qho tsis xws luag, xws li kev hloov xim, muaju, lossis nag lossis daus, nres siv tam sim ntawd.

Siv cov tshuaj raws li hnub tas sij hawm thiab kev cia khoom. Siv cov tshuaj tshiab xwb.

Thaum kawg, thaum siv thiab khaws cia, thov ua raws li cov lus qhia ntxaws ntxaws los ntawm cov chaw tsim khoom thiab nrhiav kev qhia los ntawm koj tus kws kho mob lossis tus kws muag tshuaj.

Ntim:

Shipping:

Xi'an Yihui tuam txhab muaj cov hauv qab no zoo:

Kev ruaj ntseg zoo: peb siv high-purity lead-free ntau lawm technology. Cov khoom tau dhau los ua ntau yam kev tsim khoom nruj thiab cov txheej txheem kuaj xyuas kom paub meej cov khoom zoo.

Tus nqi tsim nyog: peb muaj tus nqi tsim nyog piv rau cov khoom zoo sib xws.

Cov kev pabcuam zoo tshaj plaws: peb muaj cov kws tshaj lij kev pabcuam thiab pab pawg pabcuam tomqab muag, yog li peb tuaj yeem muab kev pabcuam kev tshaj lij thiab kev pabcuam tomqab muag los xyuas kom cov neeg siv khoom tau txais kev paub zoo tshaj plaws.

Unified hom duab: peb txais ib lub logo sib koom ua ke thiab tsim qauv ntawm cov khoom ntim, ua kom yooj yim rau cov neeg siv khoom kom paub txog lub hom phiaj thiab pab txhawb lub hom lag luam.

Xi 'an Yihui tuam txhab muag khoom, khoom siv ntau lawm

Xi'an Yihui tuam txhab muaj qib siab ntawm kev tshawb fawb thiab kev txhim kho muaj peev xwm

Xi'an Yihui Lub Tuam Txhab Advanced ntau lawm cov cuab yeej thiab thev naus laus zis

Zoo meej kev pab cuam tom qab muag

Hauv kev xaus, raws li tus kws tshaj lij5-azacytidine hmoovchaw tsim tshuaj paus, peb muaj advanced technology, scale kom zoo dua, qhov zoo tshaj plaws zoo, nplua nuj ntau lawm kev, thiab cov kev pab zoo heev. Cov txiaj ntsig zoo no yuav ua rau peb5-azacytidine APIsawv tawm hauv kev sib tw ua lag luam thiab yeej ntau tus neeg siv khoom ntseeg siab thiab kev txhawb nqa.

Cim npe nrov: 5-azacytidine hmoov, Tuam Tshoj 5-azacytidine hmoov manufacturers, lwm tus neeg, Hoobkas