Bortezomib hmoov

Bortezomib Supplier

Xi'an Yihui tuam txhab yog cov chaw tsim khoom ntawm Bortezomib. Peb tuaj yeem tsim Bortezomib nrog 99.9% cov ntsiab lus. Nws tuaj yeem siv rau hauv cov khoom noj, tshuaj, khoom siv kho mob, lossis tshuaj pleev ib ce thiab ua tau raws li USP, BP, EP, CP cov qauv. Peb tuaj yeem muab koj cov khoom ntawm qhov siab tshaj plaws caliber ntawm tus nqi sib tw tshaj plaws. Koj qhov kev xaiv zoo tshaj plaws rau lub npe nrov ntshiab Bortezomib tsum yog Xi'an Yihui Company!

Peb qhov zoo dua

Kev nplua nuj experice: peb muaj 13 Xyoo kev ua haujlwm;

Cov neeg siv khoom thoob plaws lo lus: muag rau ntau tshaj 100 lub teb chaws;

Muab cov khoom sib txawv: cov khoom lag luam tau siv rau txhua lub npe thoob ntiaj teb loj hauv kev lag luam tshuaj, tshuaj noj, tshuaj pleev ib ce, tsiaj noj khoom haus thiab khoom noj khoom haus.

Nqe ua ntej: qis MOQ nrog tus nqi sib tw;

Daim ntawv pov thawj zoo: ISO; Halal; Kosher tau ntawv pov thawj

Kev pab cuam tom qab muag: Pab neeg tshaj lij 7 * 24 teev cov neeg siv khoom.

Bortezomib yog dab tsi?

Bortezomib hmoovfeem ntau yog siv los ua proteasome inhibitor. Nws lub npe tshuaj yog [(1R) -3-methyl{2}} [(2S) -1-oxo-3-phenyl-2- [(pyrazin-2-} ylcarbonyl) amino] propyl] amino] butyl] boronic acid, nws cov tshuaj formula yog C19H25BN4O4, nws qhov hnyav molecular yog 384.24 g / mol, thiab nws tus lej CAS yog179324-69-7. Nws cov qauv tshuaj yog ib qho epoxyketone compound uas muaj boron, uas tuaj yeem khi rau qhov chaw nquag ntawm cov qauv proteasome tertiary hauv cell thiab thaiv nws cov haujlwm, yog li inhibiting cell loj hlob thiab kev loj hlob.

Nws yog xim dawb mus rau daj me ntsis nrog lub melting point ntawm 122 degree thiab 125 degree. Nws yog me ntsis soluble hauv dej, soluble hauv DMSO thiab methanol. Nws muaj ib pawg boronic ester rotatable, uas ua rau nws yooj yim hydrolyzed nyob rau hauv kev daws, yog li nws yuav tsum tau muab khaws cia thiab siv nyob rau hauv qhuav thiab noo-dawb ib puag ncig. Nws yuav tsum tau khaws cia rau hauv qhov chaw qhuav, txias, thiab tsaus, nyiam dua hauv lub thawv airtight kom nws ruaj khov.

Nws qhov kev tshawb pom tau pib thaum xyoo 1990s, pib tshawb fawb los ntawm pab pawg kws tshawb fawb los ntawm ProScript, lub tuam txhab biotechnology hauv New York, Tebchaws Asmeskas (tom qab tau txais los ntawm Millennium Pharmaceuticals). Lawv siv cov nyhuv ntawm proteasomes ntawm neuronal cell loj hlob thiab kev sib txawv thiab soj ntsuam cov muaj peev xwm inhibitors, suav nrogBortezomibAPI.

Tom qab ntawd, cov tshuaj tau hu ua PS-341, thiab tom qab xyoo ntawm kev tshawb fawb thiab kev sim tshuaj, nws tau raug pom zoo los ntawm US FDA thaum lub Kaum Ib Hlis 20, 2003 ua thawj proteasome inhibitor siv los kho ntau yam myeloma. Txij thaum ntawd los, nws kuj tau txais kev pom zoo los ntawm cov teb chaws thiab cheeb tsam xws li EU, Canada, thiab Nyij Pooj, dhau los ua ib qho tseem ceeb siv tshuaj.

Nyob rau hauv txoj kev loj hlob, cov kws tshawb fawb tsis tu ncua txhim kho thiab nkag siab tob txog cov txheej txheem lom neeg ntawm proteasomes, txhawb kev tshawb fawb thiab kev loj hlob hauv cov haujlwm muaj feem xyuam.

Cov ntaub ntawv tseem ceeb:

Cov qauv zoo:

Tsuas yog siv rau kev lag luam lossis kev tshawb fawb, tsis yog khoom siv rau ib tus neeg twg!

Muaj nuj nqi thiab kev siv

Bortezomib yog ib qho proteasome inhibitor siv feem ntau ua cov tshuaj khomob los kho ntau hom qog noj ntshav, suav nrog ntau yam myeloma thiab mantle cell lymphoma. Nws siv nws txoj kev kho mob los ntawm kev thaiv cov kev ua ntawm proteasomes, uas yog cov txheej txheem cellular lub luag haujlwm rau kev rhuav tshem cov proteins uas tseem ceeb rau kev loj hlob thiab ciaj sia ntawm cov qog nqaij hlav cancer.
Nov yog cov haujlwm tseem ceeb thiab kev siv ntawm Bortezomib:
1. Inhibition ntawm proteasomal kev ua ub no: Lub hauv paus txheej txheem ntawm kev ua yog nws muaj peev xwm mus inhibit lub proteasome, ib tug tseem ceeb cellular tshuab uas lov cov proteins, nrog rau cov uas ua rau cov qog nqaij hlav cancer loj hlob thiab proliferate. Los ntawm inhibiting proteasomal kev ua ub no, nws ua rau ib tug cascade ntawm cov xwm txheej uas thaum kawg ua rau kev tuag ntawm cov qog nqaij hlav cancer.
2. Kev kho mob ntawm ntau yam myeloma: Ntau yam myeloma yog ib hom mob qog noj ntshav uas cuam tshuam rau cov ntshav plasma, yog hom ntshav dawb. nws tau pom zoo los ntawm US FDA rau kev kho mob ntawm ntau yam myeloma, xws li kev kho ib leeg lossis ua ke nrog lwm cov tshuaj khomob. Nws tau pom tias yuav txhim kho cov ciaj sia taus thiab lub neej zoo nyob rau hauv cov neeg mob uas muaj tus mob no.
3. Kev kho mob ntawm mantle cell lymphoma: nws kuj yog siv los kho mantle cell lymphoma, ib hom tsis tshua muaj ntawm Hodgkin's lymphoma uas cuam tshuam rau cov qog nqaij hlav, pob txha pob txha, thiab lwm yam kabmob. Nws feem ntau yog siv ua ke nrog lwm cov tshuaj chemotherapy thiab tau pom tias muaj txiaj ntsig zoo hauv kev ua kom tshem tawm cov neeg mob uas muaj tus mob no.
4. Hom kev kho mob: nws yog ib qho kev kho mob uas xaiv hom kab mob qog noj ntshav, ua rau cov hlwb noj qab haus huv tsis raug mob. Qhov no ua rau nws tsis muaj tshuaj lom ntau dua li lwm cov tshuaj chemotherapy, uas tuaj yeem ua rau muaj kev phiv loj heev.
5. Cov txiaj ntsig tau zoo hauv cov neeg tau txais kev hloov pauv: nws tau pom tias yuav txhim kho cov txiaj ntsig ntawm cov neeg mob uas tau hloov cov qia cell, ib txoj kev siv los kho cov pob txha pob txha hauv cov neeg mob uas muaj qee yam mob qog noj ntshav. Los ntawm kev txo qhov kev pheej hmoo ntawm kev tsis lees txais cov khoom lag luam thiab txhim kho kev koom tes ntawm cov neeg pub dawb, nws tau pom tias txhim kho tag nrho cov ciaj sia nyob hauv cov neeg mob no.
Nyob rau hauv xaus, nws yog ib tug muaj zog chemotherapy tus neeg sawv cev uas inhibits proteasomal kev ua si, ua rau kom tuag ntawm cov qog nqaij hlav cancer. Nws yog siv feem ntau los kho ntau yam myeloma thiab mantle cell lymphoma thiab feem ntau siv ua ke nrog lwm cov tshuaj khomob. Raws li cov phiaj xwm kev kho mob, nws xaiv lub hom phiaj ntawm cov qog nqaij hlav cancer, ua rau nws tsis tshua muaj kev phom sij rau cov hlwb noj qab haus huv thiab txo cov kev pheej hmoo ntawm kev mob tshwm sim.

Stability & Solubility:

Bortezomib hmoovmuaj qee qhov tsis ruaj khov uas yuav cuam tshuam rau nws qhov chaw cia thiab kev siv. Nws yog nquag mus rau hydrolysis nyob rau hauv kev daws, qhov twg boronic ester pawg yuav cleaved los ntawm cov molecule thiab tsim inactive metabolic khoom. Nws kuj tau yooj yim cuam tshuam los ntawm yam xws li oxidation, hydrolysis, thiab photolysis, ua rau kom degradation sai.

Yuav kom muaj kev ruaj ntseg, cov kev ntsuas hauv qab no yuav tsum tau ua:

Tsis txhob sib cuag nrog cov av noo thiab av noo ib puag ncig thaum khaws cia thiab thauj, thiab ua kom qhuav.

Khaws rau hauv qhov chaw txias, qhuav, thiab tsaus. muab tso rau hauv ib lub thawv kaw

Tsis txhob rov qab khov-thaw cycles vim qhov no tuaj yeem ua rau crystallization thiab decomposition.

Siv cov kuab tshuaj qhuav los npaj cov kev daws teeb meem, thiab yaj lawv ntawm qhov kub thiab txias tam sim ua ntej siv.

Tsis txhob tuav lub sij hawm ntev, tshwj xeeb tshaj yog thaum lub sij hawm dissolution.

Thaum siv nws, tiv thaiv nws los ntawm oxidation, hydrolysis, los yog lub teeb raug.

Hauv cov ntsiab lus, kev khaws cia thiab kev siv tsim nyog yuav tsum tau coj los tswj kev ruaj ntseg thiab tsis txhob muaj yam tsis tsim nyog uas yuav cuam tshuam rau nws.

Ntim:

Shipping:

Cov neeg siv khoom tawm tswv yim

Xi'an Yihui daim ntawv pov thawj

Raws li tus kws tshaj lijBortezomib APIcov tuam txhab tsim khoom, Xi 'an Yihui tuam txhab tsom mus rau cov khoom zoo thiab kev ruaj ntseg, lub tuam txhab tau dhau GMP ntawv pov thawj, thiab tsim kom muaj kev tswj hwm zoo thiab nruj, kom ntseeg tau tias cov khoom ua tau raws li lub teb chaws cov qauv thiab cov neeg siv khoom.

Xi 'an Yihui tuam txhab muag khoom, khoom siv ntau lawm

Xi'an Yihui tuam txhab muaj qib siab ntawm kev tshawb fawb thiab kev txhim kho muaj peev xwm

Xi 'an Yihui Company's Advanced ntau lawm cov cuab yeej thiab tshuab

Zoo meej kev pab cuam tom qab muag

Los xaus, Xi 'an Yihui Tuam Txhab ua tus kws tshaj lij kev tsim khoom ntawmBortezomib hmoov, nrog cov khoom lag luam zoo, qib siab ntawm kev tshawb fawb thiab kev tsim kho muaj peev xwm, cov khoom siv ntau lawm thiab kev siv tshuab, kev pabcuam zoo tom qab muag thiab lwm yam zoo, yog cov neeg siv khoom xaiv ntawm tus khub zoo tagnrho.

Yog tias koj xav tau, pls xav tiv tauj peb txhua lub sijhawm. peb yuav teb koj asap.

peb cov ntaub ntawv tiv tauj:

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