Khoom Description
Capecitabine yog dab tsi?
Capecitabine hmoovyog ib qho prodrug uas tau hloov mus rau hauv cov metabolite nquag 5-fluorouracil (5-FU) hauv lub cev los ntawm kev ua ntawm ntau cov enzymes los ua kom nws cov nyhuv.Capecitabine APIyog ib yam khoom uas muaj nyob hauv cov hmoov dawb los yog yuav luag dawb crystalline hmoov. Nws lub npe tshuaj yog 5'-deoxy-5-fluoro-N-[(pentyloxy)carbonyl]-cytidine. Nws yog ib qho pyrimidine analog, uas txhais tau hais tias nws zoo ib yam li pyrimidine. Nws cov mis molecular yog C15H22FN3O6, thiab nws qhov hnyav molecular yog 359.35 g / mol. CAS tus lej rau capecitabine yog154361-50-9. Nws yog me ntsis soluble hauv dej thiab yooj yim soluble hauv cawv (ethanol).
Cov keeb kwm kev loj hlob ntawm capecitabine yog raws li nram no:
Thaum ntxov 1980s: Nws yog thawj zaug synthesized thiab raug rau thawj zaug tshuaj ntsuam xyuas hauv kev tshawb fawb los ntawm lub tuam txhab kws tshuaj Roche.
1997: Kev sim tshuaj kho mob tau pib. Thaum lub sij hawm cov kev sim no, cov kws tshawb fawb pom tias nws tau pom tias muaj txiaj ntsig zoo rau kev tswj hwm cov hlab ntsha ntawm 5-fluorouracil (5-FU), tab sis nrog kev kam rau siab dua thiab txoj hauv kev yooj yim dua ntawm kev tswj hwm.
1998: US Food and Drug Administration (FDA) tau pom zoo rau kev lag luam ntawm nws.
Kev tshawb fawb ntxiv thiab kev txhim kho: Sij hawm dhau los, kev tshawb fawb ntawm nws tau txuas ntxiv nrog lub hom phiaj ntawm kev ua kom zoo dua, kev kho mob, thiab cov tswv yim kho mob ua ke los txhim kho kev ua tau zoo thiab txo cov kev mob tshwm sim.
Hauv cov ntsiab lus, nrog rau kev tshawb fawb ntxiv thiab kev xyaum kho mob, peb tuaj yeem cia siab tias yuav txhim kho txuas ntxiv thiab nkag siab tob txog nws thiab nws cov kev siv.
Cov ntaub ntawv tseem ceeb:
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Khoom npe |
Capecitabine |
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Tshuaj npe |
5'-deoxy-5-fluoro-N-[(pentyloxy)carbonyl]-cytidine |
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CAS |
154361-50-9 |
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MF |
C15H22FN3O6 |
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MW |
359.35 |
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EINECS |
604-948-1 |
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MDL Nr. |
TIAB SA 00930626 |
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Purity |
99 feem pua |
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Kev ruaj ntseg |
ruaj khov |
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Daim ntawv thov |
Qib Tshuaj & Kev Tshawb Fawb Qib. |
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Ntim |
Raws li koj qhov kev thov |
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Cia |
Chav ntsuas kub. |
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Cov qauv qauv |
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Cov qauv zoo:
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Cov khoom kuaj |
Specifications |
Kev tshwm sim |
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Qhov tshwm sim |
Dawb mus rau dawb crystalline hmoov. |
Off-dawb crystalline hmoov |
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Solubility |
Dawb soluble hauv methanol; Soluble hauv Acetonitrile thiab hauv cawv. Sparingly soluble hauv dej. |
Ua raws |
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Kev txheeb xyuas |
Infrared Absorption |
Ua raws |
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Lub sijhawm khaws cia ntawm lub ncov loj hauv chromatogram ntawm kev soj ntsuam sib raug rau qhov hauv chromatogram ntawm tus qauv siv. |
Ua raws |
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Kev txiav txim siab dej |
Tsawg dua lossis sib npaug rau 0.3 feem pua |
0.02 feem pua |
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Kev hloov kho qhov muag |
ntxiv rau 96.0 degree ~ ntxiv rau 100.0 degree |
ntxiv rau 97.5 degree |
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Residue ntawm Ignition |
Tsawg dua lossis sib npaug rau 0.1 feem pua |
0.01 feem pua |
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Cov hlau hnyav |
Tsawg dua lossis sib npaug li 20ppm |
Ua raws |
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Cov khoom muaj feem xyuam |
Capecitabine muaj feem xyuam nrog A Tsawg dua lossis sib npaug rau 0.3 feem pua |
ND |
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Capecitabine muaj feem xyuam nrog B Tsawg dua lossis sib npaug rau 0.3 feem pua |
0.03 feem pua |
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2,3-Di-O-acetyl-5′-deoxy-5-fluorocytidine Tsawg dua lossis sib npaug rau 0.10 feem pua |
0.02 feem pua |
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5-Deoxy-5-fluoro-N4-(2-methyl-1-butyloxycarbonyl)cytidine ntxiv rau 5-Deoxy-5-fluoro-N4-(3-}methyl-1-butyloxycarbonyl)cytidine Tsawg dua lossis sib npaug rau 0.5 feem pua |
ND |
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[{{0}}}[5-Deoxy-3-O-(5-deoxy- -D- ribofuranosyl )- -D- ribofuranosyl]-5-fluoro-2-oxo-1,2-dihydropyl estersin {12}}dihydropylba (dihydropyri) rau 0.3 feem pua |
ND |
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[{{0}}}[5-Deoxy-2-O-(5-deoxy- -D- ribofuranosyl )- -D- ribofuranosyl]-5-fluoro-2-oxo-1,2-dihydropyl-methyl methylba (dihydropylba) vaj huam sib luag ntawm cov tshuaj esters rau 0.2 feem pua |
ND |
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Capecitabine muaj feem xyuam nrog C Tsawg dua lossis sib npaug rau 0.3 feem pua |
ND |
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[{{0}}}[5-Deoxy-2-O-(5-deoxy- -D- ribofuranosyl )- -D- ribofuranosyl]-5-fluoro-2-oxo-1,2-dihydropyl-methyl methylba (dihydropylba) vaj huam sib luag ntawm cov tshuaj esters rau 0.3 feem pua |
ND |
|
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2,3-Di-O-acetyl-5-deoxy-5-fluoro-N4-(pentyloxycarbonyl) cytidine Tsawg dua lossis sib npaug rau 0.1 feem pua |
ND |
|
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Tus neeg tsis paub meej impurity Tsawg dua lossis sib npaug rau 0.1 feem pua |
0.03 feem pua |
|
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Tag nrho impurities Tsawg dua lossis sib npaug li 1.5 feem pua |
0.10 feem pua |
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Assay |
98%. |
99.9% ua |
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Xaus: Tag nrho cov txiaj ntsig ua raws li qhov yuav tsum tau ua ntawm USP |
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Ntim thiab khaws cia: Khaws rau hauv cov thawv ntim nruj. Khaws ntawm chav tsev kub tswj. |
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Tsuas yog siv rau kev lag luam lossis kev tshawb fawb, tsis yog khoom siv rau ib tus neeg twg!
Kev ruaj ntseg:
Capecitabine hmoovstability yog cuam tshuam los ntawm ntau yam. Ntawm no yog cov ncauj lus kom ntxaws stability:
Kub: Nws yog qhov ruaj khov ntawm chav tsev kub. Feem ntau, nws raug nquahu kom khaws cia rau hauv qhov kub ntawm 15 degree txog 30 degree (59 degree F txog 86 degree F). Tsis txhob raug rau qhov kub thiab txias heev.
Humidity: Nws yog rhiab heev rau cov av noo. Nws yog ib qho tseem ceeb uas yuav tsum tau khaws cia rau hauv qhov chaw qhuav kom tsis txhob muaj dej noo thiab cov tshuaj tiv thaiv hydrolysis. Nws raug nquahu kom khaws cia rau hauv qhov chaw nrog cov av noo tsis tshaj 65 feem pua.
Lub teeb: Nws yog photosensitive, tshwj xeeb tshaj yog rau UV teeb. Yog li ntawd, nws yuav tsum tau muab cia rau hauv lub teeb-resistant ntim, deb ntawm ncaj qha tshav ntuj.
Chemical instability: Nws yuav hnov mob nrog lwm yam tshuaj, ua rau degradation los yog instability. Yog li ntawd, thaum lub sij hawm cia thiab siv, nws raug nquahu kom tsis txhob sib cuag nrog oxidizing neeg sawv cev, acidic tshuaj, thiab hlau ions.
Ntxiv nrog rau cov xwm txheej no, kev ntim khoom kom raug thiab kev sib khi tseem ceeb kuj tseem ceeb hauv kev tswj nws txoj kev ruaj ntseg. Khaws cia rau hauv cov thawv ntim zoo kom tsis txhob raug huab cua, noo noo, lossis cov khoom paug. Hauv cov ntsiab lus, kom nws ruaj khov, nws yuav tsum muab cia rau hauv qhov chaw qhuav, txias, thiab tiv thaiv lub teeb, thiab khaws cia kom deb ntawm cov av noo, qhov kub thiab txias, lub teeb, thiab cov khoom tsis zoo.
Cia:
Cov xwm txheej cia rau Capecitabine yog raws li hauv qab no:
Kub: Khaws nws ntawm chav tsev kub, feem ntau pom zoo nyob rau hauv thaj tsam ntawm 15 degree txog 30 degree (59 degree F txog 86 degree F).
Ntim: Xyuas kom nws khaws cia rau hauv lub thawv qhuav thiab zoo kaw. Thawj ntim yog qhov kev xaiv zoo tshaj plaws raws li lawv tau tsim tshwj xeeb los tiv thaiv kev ruaj ntseg ntawm cov tshuaj.
Kev tiv thaiv lub teeb: Nws yog photosensitive thiab raug rau lub teeb yuav ua rau nws degradation. Yog li ntawd, thaum lub sij hawm cia, nws yuav tsum tau khaws cia nyob rau hauv lub teeb-tiv thaiv thawv kom ntau li ntau tau kom txo tau qhov cuam tshuam ntawm lub teeb raug.
Humidity: Nws yog rhiab heev rau cov av noo thiab tuaj yeem nqus cov dej noo thiab ua rau cov tshuaj tiv thaiv hydrolysis. Txhawm rau zam qhov no, nws yuav tsum tau muab cia rau hauv qhov chaw qhuav thiab xyuas kom lub thawv ntim tau zoo.
Cia qhov chaw: Khaws cia rau hauv qhov chaw deb ntawm cov av noo, qhov chaw tshav kub, thiab cov tshuaj phem.
Thov nco ntsoov tias cov lus pom zoo khaws cia no yog rau kev siv dav dav. Cov xwm txheej tshwj xeeb khaws cia yuav txawv nyob ntawm hom, chaw tsim khoom, lossis cov cai tshwj xeeb ntawm cov tshuaj.
Packing & shipping
Ntim:
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1 ~ 2 kg |
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2-10kg |
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10-25kg |
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Shipping:
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Tsawg dua los yog sib npaug li 50 kg |
Los ntawm kev nthuav qhia qhov rooj rau qhov rooj Fedex, DHL, UPS, TNT, EMS thiab lwm yam. Ceev thiab yooj yim |
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50kg-200kg |
Los ntawm huab cua Ceev thiab pheej yig |
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Ntau tshaj lossis sib npaug li 200kg |
Los ntawm hiav txwv Txoj kev pheej yig tshaj |
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Los yog raws li koj yuav tsum tau xaiv txoj kev pheej yig tshaj los yog ceev. |
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Lub sijhawm them nyiaj
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Xi 'an Yihui Company's Advanced ntau lawm cov cuab yeej thiab tshuab
Xi'an Yihui tuam txhab muaj kev pabcuam zoo tom qab muag
Xi'an Yihui tuam txhab ua raws li lub tswv yim ntawm kev lav phib xaub thiab kev tsim kho kom ruaj khov, hauv cov txheej txheem ntawm kev tsim khoom thiab kev tswj xyuas ib txwm tsom rau kev tiv thaiv ib puag ncig, kev nyab xeeb zoo thiab kev lav phib xaub, txhawb kev lag luam kom ruaj khov raws li lub hom phiaj.
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