Cycloheximide hmoov

Cycloheximide yog dab tsi?

Cycloheximide hmoovyog ib yam khoom ntuj tsim thiab tshuaj tua kab mob uas feem ntau siv rau hauv kev tshawb fawb lom thiab biochemical. Nws yog dawb crystalline hmoov. Nws yog soluble hauv dej thiab feem ntau cov kuab tshuaj organic. Nws exerts nws cov tshuaj tua kab mob feem ntau los ntawm inhibiting protein synthesis. Nws muaj zog inhibitory teebmeem ntawm fungi thiab qee yam protozoa. Nws lub npe tshuaj yog N-methyl-N-(6-aminohex-2-enoyl)-L-proline, nws cov mis molecular yog C15H23NO4, nws qhov hnyav molecular yog 281.34 g / mol. CAS nr66-81-9.

Cycloheximide APImuaj ntau yam kev siv hauv kev tshawb fawb txog biological, suav nrog:

Protein translation inhibition: Nws inhibits kev ua ntawm ribosomes, yog li thaiv cov protein synthesis. Nws yog feem ntau siv los kawm txog cov txheej txheem xws li protein degradation, kev tswj hwm, thiab kev lag luam.

Kab lis kev cai nruab nrab tivthaiv: Nws tuaj yeem muab ntxiv rau hauv kab lis kev cai xov xwm los tiv thaiv kev loj hlob ntawm cov kab mob fungi, tso cai rau kev xaiv loj hlob los yog tshuaj xyuas cov kab mob hloov pauv.

Kev tshawb fawb txog lub voj voog ntawm tes: Nws tuaj yeem siv los ntes cov hlwb ntawm cov theem tshwj xeeb ntawm lub voj voog ntawm tes, ua rau kev kawm txog cov txheej txheem xws li cell proliferation, sib txawv, thiab apoptosis.

RNA synthesis inhibition: Nws tuaj yeem cuam tshuam cov txheej txheem ntawm RNA synthesis thiab siv los kawm txog kev tswj hwm kev hloov pauv thiab cov noob qhia.

Nov yog qee qhov tseem ceeb hauv paus ntsiab lus thiab kev tshawb fawb loj hlob tuaj:

1949: Nws tau raug rho tawm thawj zaug los ntawm Asmeskas cov kws tshawb fawb H. Raistrick thiab SA Smith los ntawm actinomycete Streptomyces griseus, thiab nws cov qauv siv lead ua tau ua tiav.

Xyoo 1950: Nws tau tshawb pom nws cov tshuaj tiv thaiv kab mob. Cov kws tshawb nrhiav pom tias cov khoom sib xyaw ua rau muaj zog inhibitory cuam tshuam rau cov kab mob fungi, thaum muaj kev cuam tshuam me me rau cov kab mob thiab cov tsiaj txhu.

1963: Ib feem elucidation ntawm nws cov txheej txheem ntawm kev ua.

1973: Kev tshawb nrhiav ntxiv rau nws cov tshuaj tiv thaiv kab mob. Cov kws tshawb nrhiav pom tias nws tuaj yeem cuam tshuam lub peev xwm ntawm tRNA zoo li cov molecules los khi rau A site, yog li tiv thaiv aminoacyl tRNA los ntawm kev nkag mus rau Ribosome.

Txij li thaum xyoo 1980, nws daim ntawv thov tau nthuav dav mus rau ntau qhov chaw. Nws yog siv los kawm txog protein synthesis thiab degradation, cell cycle, gene expression regulation, thiab ntau lwm yam.

Niaj hnub no, nws tau dhau los ua ib qho ntawm cov cuab yeej tseem ceeb hauv kev tshawb fawb txog kev tshawb fawb. nws cov txheej txheem ntawm kev txiav txim txuas ntxiv mus kawm hauv qhov tob. Nrog kev nce qib hauv kev tshawb fawb thev naus laus zis, ntau cov ntsiab lus tshwj xeeb tau raug tshawb pom thiab siv hauv kev tshawb fawb ntsig txog. Txawm li cas los xij, nws tseem tuav nws lub luag haujlwm tseem ceeb hauv ntau qhov kev sim.

Cov ntaub ntawv tseem ceeb:

Cov qauv zoo:

Tsuas yog siv rau kev lag luam lossis kev tshawb fawb, tsis yog khoom siv rau ib tus neeg twg!

Cia:

Cycloheximide hmoovCov xwm txheej khaws cia yog raws li hauv qab no:

Kub: Nws yuav tsum tau muab cia rau hauv chav tsev kub, tsis txhob muaj qhov kub thiab txias. Qhov ntsuas kub tau pom zoo yog 2-8 degrees Celsius.

Kev tiv thaiv lub teeb: Nws yuav tsum tau ceev kom deb ntawm lub hnub ncaj qha thiab lub teeb muaj zog. Nws tuaj yeem muab khaws cia rau hauv cov thawv opaque lossis cov hnab ntim kaw kom tiv thaiv nws ntawm lub teeb raug.

Ib puag ncig qhuav: Nws yuav tsum muab cia rau hauv qhov chaw qhuav, tsis txhob ya raws. Cov ntim ntim kaw lossis cov khoom siv desiccants tuaj yeem siv los tswj kom qhuav.

Sealing: Lub thawv yuav tsum tau muab kaw kom nruj kom tsis txhob muaj cua thiab noo noo nkag mus. Xyuas kom lub hau los yog lub hau ntim kom ruaj ntseg kom tiv thaiv tau cov khoom volatilization los yog paug.

Tsis txhob khov-thaw cycles: Nquag khov thiab thawing yuav tsum tau zam vim nws yuav txo tau nws qhov zoo thiab ua tau zoo. Nws raug nquahu kom aliquot nws mus rau qhov tsim nyog siv qhov ntau thiab tsawg kom tsis txhob muaj ntau qhov qhib.

Thov nco ntsoov tias cov saum toj no yog cov txheej txheem khaws cia. Tej zaum yuav muaj qhov sib txawv me ntsis nyob ntawm tus neeg muag khoom thiab hom khoom. Thov ua raws li cov lus qhia tshwj xeeb ntawm daim ntawv lo rau kev khaws cia.

Ntim:

Shipping:

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Xi'an Yihui tuam txhab muaj qib siab ntawm kev tshawb fawb thiab kev txhim kho muaj peev xwm

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Hauv kev xaus, raws li covCycloheximide hmoovchaw tsim tshuaj paus, peb yuav muab cov neeg muas zaub nrog high-zooCycloheximide APIthiab cov kev pabcuam tshaj lij.

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