Alprostadil hmoov

Alprostadil hmoov yog dab tsi?

Alprostadil hmoov, kuj hu uaProstaglandin E1,Prostadil, Caverject, PGE 1, yog ib yam tshuaj lom neeg muaj nyob rau hauv lub cev. Nws belongs rau tsev neeg prostaglandin thiab tau lees paub tias yog ib qho endogenous physiological active tshuaj. Prostaglandin E1 ncaj qha ua rau vascular du nqaij, dilates cov hlab ntsha, ua kom cov ntshav txaus, txhim kho microcirculation perfusion; inhibits platelet aggregation thiab thromboxane A2 tiam, inhibits atherosclerosis, lipid plaque, thiab kev tiv thaiv kab mob; dilates peripheral me cov hlab ntsha thiab coronary hlab ntsha, txo peripheral vascular kuj thiab ntshav siab, tiv thaiv platelet cell membranes, tiv thaiv thrombus tsim; tiv thaiv ischemic myocardium, txo qhov chaw myocardial infarction; tiv thaiv lub plawv tsis ua hauj lwm; dilates raum cov hlab ntsha, ua rau kom cov ntshav khiav, tshem tawm cov tsis muaj protein ntau nitrogen, tswj cov dej thiab sodium sib npaug, muaj cov nyhuv diuretic thiab raum tiv thaiv. Nws muaj ib nrab-lub neej ntawm 5-10 feeb, nrog 68 feem pua ​​​​yog metabolized hauv daim siab thiab tawm los ntawm lub raum. Clinically, nws yog siv rau tej yam kev mob xws li angina pectoris, myocardial infarction, pulmonary arterial hypertension, thiab mob hlab ntsha occlusion. Cov khoom no yog ib tug dawb los yog daj ntseg daj koob-zoo li tus crystal nrog ib tug melting point ntawm 115-116 degree thiab ib tug tshwj xeeb kev sib hloov ntawm -61.6 degree (c=0.56 hauv THF). Nws yog yooj yim soluble nyob rau hauv ethyl ether.

Cov ntaub ntawv tseem ceeb:

Khoom npe: Alprostadil; PGE1; Prostaglandin E1

CAS:745-65-3

MF: C20H34O5

MW: 354.49

EINECS:212-017-2

Melting point: 115-116 degree

cia temp. -20 degree

Purity: 99 feem pua

Stability: ruaj khov rau 2 xyoos

Daim ntawv thov: siv rau kev tshawb fawb.

Packing: Raws li koj qhov kev thov

Tus qauv qauv:

Cov qauv zoo:

Txheej txheem ntau lawm:

a. Tau txais yaj cov hlwv.

b.Homogenize cov hlab ntsha hauv cov tshuaj uas muaj KCl thiab EDTA-Na2 ntawm pH 8 kom tau txais kev sib xyaw ntawm cov enzymes.

c. Ua kom cov enzyme sib xyaw nrog hydrogen peroxide, glutathione, thiab dihomo- -linolenic acid.

d. Extract cov tshuaj tiv thaiv sib xyaw nrog acetone, ether, thiab dichloromethane.

e. Tau txais crude prostaglandins.

f. Sib cais prostaglandin E1 los ntawm cov khoom nyoos siv cov silica gel kem.

Txoj kev tsim khoom:

• Siv yaj seminal vesicles ua raw khoom
• Kev npaj cov khoom siv raw PGE siv yaj cov hlwv cov hlwv raws li cov khoom siv raw muaj kev npaj enzymatic, incubation, organic solvent extraction, thiab silica gel kem sib cais.
• Sheep seminal vesicles [KCl, EDTA-Na2, pH 8] → Enzyme mix [hydroquinone, glutathione] → Reaction mix [arachidonic acid, O2] → Solvent mix [acetone, ether, dichloromethane] → Crude PGS khoom [sib cais] → [silica] gel kem] Crude PGE khoom.
• Rau kev npaj ntawm PGE1 cov khoom kawg, rau txhua 1g ntawm crude PGE khoom, siv 20g ntawm silica gel. Ua kom cov silica gel los ntawm kev sib xyaw nrog cov nyiaj nitrate hauv qhov sib piv ntawm V ethyl acetate: V glacial acetic acid: V roj av ether: V dej=220: 22.5: 125: 5 (petroleum ether boiling point 90-120} degree) raws li tus neeg sawv cev tsim. Ua kem chromatography siv txoj kev ntub dej. Dissolve ib tug me me ntawm cov khoom crude nyob rau hauv tib txoj kev loj hlob tus neeg sawv cev, thauj nws mus rau kem, thiab elute. Sau cov seem ntawm PGE1 thiab PGE2. Ua kom pom tseeb ntawm PGE1 feem hauv qab nitrogen ntawm qhov kub qis dua 35 degree kom tshem tawm cov ntxhiab tsw ntawm acetic acid. Dissolve nws nyob rau hauv ethyl acetate, ntxuav nrog acidic dej ntawm pH 4-5, thiab tshem tawm cov nyiaj siv physiological saline tov. Tso cov tshuaj ethyl acetate hauv lub tub yees thaum hmo ntuj kom tau txais PGE1 cov khoom kawg.
• Crude PGE khoom [silver nitrate silica gel kem] → PGE1
• Siv -linolenic acid methyl ester ua cov khoom pib thiab siv cov tshuaj-enzymatic synthesis technology, prostaglandin E1 yog synthesized los ntawm ob txoj kev sib txawv, nrog rau tag nrho cov yields ntawm 13 feem pua ​​thiab 16 feem pua.

Muaj nuj nqi thiab kev siv:

Alprostadil hmoovFeem ntau yog siv los kho kab mob siab, mob siab, mob stroke, ntshav qab zib, erectile kawg, thiab kab mob ua pa. Nws nthuav tawm cov teebmeem los tiv thaiv fibrotic, tshwj xeeb tshaj yog rau cov menyuam yaus A thiab B cov neeg mob uas muaj lub siab ua haujlwm tsis zoo. Nws kuj yog siv rau kev ua haujlwm induction, augmentation, lub raum tsis txaus, thiab kev tswj cov mumps thiab pancreatitis. Kev txhaj tshuaj prostaglandin E1 feem ntau yog siv rau cov mob myocardial infarction, lub plawv tsis ua hauj lwm, thrombotic vasculitis, mob ntev arterial occlusive kab mob, central retinal vein thrombosis, platelet tiv thaiv thaum lub sij hawm extracorporeal ncig, arterial angiography, vascular reconstruction phais, thiab lwm yam txheej txheem.

Stability thiab cia:

Alprostadil yog ib qho tshuaj uas ruaj khov, tab sis nws tseem yuav tsum muaj kev cia khoom tsim nyog los tswj nws txoj kev ruaj ntseg thiab kev ua tau zoo. Nov yog cov xwm txheej khaws cia rau Alprostadil:

• Kub: Alprostadil yuav tsum muab cia rau hauv tub yees ntawm 2 degree thiab 8 degree (36 degree F txog 46 degree F). Tsis txhob raug rau qhov kub thiab txias.
• Lub teeb: Khaws Alprostadil kom deb ntawm lub hnub ncaj qha lossis lub teeb ci ntsa iab kom tiv thaiv kev puas tsuaj ntawm cov tshuaj.
• Ntim: Xyuas kom meej tias lub ntim ntawm Alprostadil tsis zoo thiab kaw kom tsis txhob ya raws thiab lwm yam kab mob nkag mus.
• Hnub tas sij hawm: Thov siv Alprostadil tsis pub dhau hnub tas sij hawm raws li tau hais hauv cov lus qhia khoom lossis raws li koj tus kws kho mob qhia. Cov tshuaj uas tas sij hawm yuav plam potency los yog ua rau muaj kev phiv.

Ntim:

Shipping:

Xi'an Yihui tuam txhab muaj cov hauv qab no zoo:

Kev ruaj ntseg zoo: peb siv high-purity lead-free ntau lawm tshuab. Cov khoom tau dhau los ua ntau yam kev tsim khoom nruj thiab cov txheej txheem kuaj xyuas kom paub meej cov khoom zoo.

Tus nqi tsim nyog: peb muaj tus nqi tsim nyog piv rau cov khoom zoo sib xws.

Cov kev pabcuam zoo tshaj plaws: peb muaj cov kws tshaj lij kev pabcuam thiab pab pawg pabcuam tomqab muag, yog li peb tuaj yeem muab kev pabcuam kev tshaj lij thiab kev pabcuam tomqab muag los xyuas kom cov neeg siv khoom tau txais kev paub zoo tshaj plaws.

Unified hom duab: peb txais ib lub logo sib koom ua ke thiab tsim qauv ntawm cov khoom ntim, ua kom yooj yim rau cov neeg siv khoom kom paub txog lub hom phiaj thiab pab txhawb lub hom lag luam.

Xi 'an Yihui tuam txhab muag khoom, khoom siv ntau lawm

Xi'an Yihui tuam txhab muaj qib siab ntawm kev tshawb fawb thiab kev txhim kho muaj peev xwm

Xi'an Yihui Lub Tuam Txhab Advanced ntau lawm cov cuab yeej thiab thev naus laus zis

Zoo meej kev pab cuam tom qab muag

Hauv kev xaus, raws li tus kws tshaj lijAlprostadil hmoovchaw tsim tshuaj paus, peb muaj advanced technology, scale kom zoo dua, qhov zoo tshaj plaws zoo, nplua nuj ntau lawm kev, thiab cov kev pab zoo heev. Cov txiaj ntsig zoo no yuav ua rau pebProstaglandin E1sawv tawm hauv kev sib tw ua lag luam thiab yeej ntau tus neeg siv khoom ntseeg siab thiab kev txhawb nqa. Yog tias koj xav tau Alprostadil Powder, pls xav tiv tauj peb txhua lub sijhawm. peb yuav teb koj asap.

peb cov ntaub ntawv tiv tauj:

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