Khoom Description

Tiotropium bromide yog dab tsi?

Tiotropium bromide hmoovyog ib qho tshuaj active tshuaj. Nws yog siv rau kev kho mob ntawm obstructive pulmonary kab mob thiab bronchial hawb pob. Nws yog dawb mus rau dawb crystalline hmoov. Los ntawm kev thaiv cov receptors no, nws tuaj yeem txo cov leeg nqaij leeg, txo qis hauv cov hlab ntsha, ua kom lub bronchi, txo qhov mob thiab inflammatory teb, thiab txhim kho kev ua pa. Nws lub npe tshuaj yog (1alpha,2beta,4beta,7beta)-7-[(hydroxydi-2-thienylacetyl)oxy]-9,9-dimethyl-3-oxa{{ 10}}azoniatricyclo[3.3.1.0]nonane bromide, thiab nws cov mis molecular yog C19H22NO4Br nrog cov txheeb ze molecular hnyav ntawm 412.29 g / mol. Nws tus lej CAS yog136310-93-5. Nws muaj tsawg solubility hauv dej tab sis tuaj yeem yaj hauv cov kuab tshuaj organic xws li ethanol thiab chloroform.

Lub sijhawm ntawm nws txoj kev loj hlob yog raws li nram no:

1996-2000: Kev tshawb fawb thiab kev loj hlob ntawm tiotropium bromide tau pib thaum xyoo 1990s. Boehringer Ingelheim thiab Pfizer koom tes rau kev tshawb fawb ntawm cov tshuaj no.

2002: Nws tau txais kev pom zoo rau kev lag luam hauv lub teb chaws Yelemees, Sweden, thiab Netherlands rau kev kho mob COPD raws li cov tshuaj anticholinergic ntev. Boehringer Ingelheim tau muag nws raws li hom npe Spiriva®.

2004: US FDA pom zoo Spiriva® rau kev kho mob COPD, ua rau nws yog ib qho tshuaj uas siv ntau tshaj plaws rau COPD thoob ntiaj teb.

2005: Spiriva® kuj tau txais kev pom zoo los ntawm European Commission, ntxiv nthuav nws cov lag luam.

2012: Spiriva® Respimat® inhaler (ib lub tshuab xa khoom tshiab) tau txais kev pom zoo hauv Tebchaws Europe thiab Tebchaws Meskas. Cov cuab yeej nqus pa tshiab no muab txoj hauv kev yooj yim dua rau kev tswj hwm.

2019: Boehringer Ingelheim tshaj tawm kev koom tes nrog Eli Lilly los tsim ib qho kev kho mob sib xyaw ua ke ntawm Spiriva® Respimat® thiab Olumiant® (baricitinib) rau kev kho mob COPD hauv Asmeskas kev ua lag luam.

Txij thaum ntawd los,Tiotropium bromide APItau siv dav thoob ntiaj teb thiab tau dhau los hloov kho tas li thiab txhim kho hauv nws txoj kev xa khoom los muab kev kho mob zoo dua thiab yooj yim.

Cov ntaub ntawv tseem ceeb:

Khoom npe	Tiotropium bromide
Lwm lub npe	(1alpha,2beta,4beta,7beta)-7-[(hydroxydi-2-thienylacetyl)oxy]-9,9-dimethyl-3-oxa-9-azoniatricyclo [3.3.1.0]Nonane bromide
CAS	136310-93-5
MF	C19H22BrNO4S2
MW	472.42
EINECS	680-665-7
MDL Nr.	TIAB SA 00867027
Purity	99%
Kev ruaj ntseg	ruaj khov
Daim ntawv thov	Qib Tshuaj & Kev Tshawb Fawb Qib.
Ntim	Raws li koj qhov kev thov
Cia	Chav ntsuas kub.
Cov qauv qauv

Cov qauv zoo:

Items	Specifications	Results
Qhov tshwm sim	Dawb los yog yuav luag dawb hmoov	Dawb hmoov
Solubility	Sparingly soluble hauv methanol	Ua raws
Kev txheeb xyuas	A: IR: infrared nqus spectrum yog concordant nrog spectrum tau los ntawm tiotropium Bromide WS. B: UV: UV spectrum ntawm 0.001% w/v tov nyob rau hauv methanol nyob rau hauv thaj tsam ntawm 350nm mus rau 200nm qhia ib tug maximam ntawm txog 238nm.	Ua raws Ua raws
Kev sib hloov kho qhov muag tshwj xeeb	-0.5 degree ~ +0.5 degree	0.015 degree
Residue ntawm ignition	NMT 0.1% w/w	Ua raws
Cov hlau hnyav	NMT 20 ppm	Ua raws
Muaj feem xyuam Ib qho impurity (HPLC) Tag nrho impurities	NMT 0.2% NMT 1. 0%	0.03% 0.48%
Assay	NLT 99. 0%	99.52%
Xaus: nws ua raws li cov lus qhia saum toj no.

Tsuas yog siv rau kev lag luam lossis kev tshawb fawb, tsis yog khoom siv rau ib tus neeg twg!

Cia:

Tiotropium bromide hmoovCov xwm txheej khaws cia yog raws li hauv qab no:

Kub: Nws yuav tsum tau muab cia rau hauv chav tsev kub, nyob ib ncig ntawm 25 degree. Tsis txhob raug rau qhov kub thiab txias heev los tiv thaiv degradation ntawm cov compound.

Lub teeb: Khaws rau hauv qhov tsaus ntuj lossis qhov chaw qis qis. Tsis txhob siv lub hnub ci ncaj qha los yog lub teeb ci ntsa iab, vim tias lub teeb pom kev tuaj yeem ua rau cov khoom sib xyaw degradation.

Humidity: Nws yuav tsum muab cia rau hauv qhov chaw qhuav. Cov av noo tuaj yeem cuam tshuam rau kev ruaj ntseg ntawm cov khoom sib xyaw, yog li nws yog ib qho tseem ceeb kom tsis txhob ya raws los ntawm kev nkag mus rau hauv lub thawv ntim khoom. Koj tuaj yeem siv cov ntim ntim nruj nreem kaw los yog tuav lub ntim thawj lub foob kom tiv thaiv kom tsis txhob ya raws.

Ntim: Nws raug nquahu kom khaws cia rau hauv qhov ntim thawj zaug kom ntseeg tau tias qhov chaw cia zoo thiab tiv thaiv kev cuam tshuam sab nraud. Yog tias qhov ntim thawj yog qhib, nco ntsoov rov muab nws nruj nreem.

Huab cua raug: Tsis txhob raug huab cua ntev, tshwj xeeb tshaj yog thaum tsis kaw. Qhov no pab tiv thaiv cov compound los ntawm reacting nrog oxygen nyob rau hauv cov huab cua thiab ua rau degradation.

Thov nco ntsoov tias cov saum toj no yog cov lus pom zoo khaws cia. Txhawm rau kom ntseeg tau qhov zoo tshaj plaws khaws cia cov xwm txheej thiab kev ruaj ntseg, nws raug nquahu kom xa mus rau cov lus qhia tshwj xeeb khaws cia nrog cov khoom lag luam thiab sab laj cov chaw tsim khoom cov lus qhia.

Packing & shipping

Ntim:

1 ~ 2 kg
2-10kg
10-25kg

Shipping:

Tsawg dua los yog sib npaug li 50 kg	Los ntawm kev nthuav qhia qhov rooj rau qhov rooj Fedex, DHL, UPS, TNT, EMS thiab lwm yam. Ceev thiab yooj yim
50kg-200kg	Los ntawm huab cua Ceev thiab pheej yig
Ntau tshaj lossis sib npaug li 200kg	Los ntawm hiav txwv Txoj kev pheej yig tshaj
Los yog raws li koj yuav tsum tau xaiv txoj kev pheej yig tshaj los yog ceev.