Khoom Description
Pramipexole 2HCL monohydrate yog dab tsi?
Pramipexole dihydrochloride Monohydrateyog dopamine receptor agonist uas ua haujlwm los ntawm kev txhawb nqa dopamine D2 thiab D3 receptors los tswj cov haujlwm ntawm dopamine neurotransmitter hauv lub hlwb. Nws xaiv khi rau cov receptors no kom txo tau cov tsos mob ntawm Parkinson tus kab mob thiab nyob tsis tswm ceg syndrome. Nws yog xim dawb mus rau dawb crystalline hmoov uas yog soluble hauv dej thiab ruaj khov. Nws yog dihydrochloride ntsev dihydrate daim ntawv ntawm Pramipexole, qhov twg hydrochloride ntsev daim ntawv txhim kho nws cov dej solubility. Nws cov mis molecular yog C10H17Cl2N3S·H2O, thiab nws qhov hnyav molecular yog 302.26 g / mol. Nws tus lej CAS yog191217-81-9.
Cov keeb kwm kev loj hlob ntawm Pramipexole tuaj yeem taug qab mus rau xyoo 1990s. Nov yog qhov tseem ceeb hauv kev txhim kho cov tshuaj no:
1988: Pramipexole tau ua thawj zaug.
1993: Kev sim tshuaj ntawm Pramipexole pib rau kev kho mob ntawm cov tsos mob ntawm tus kab mob Parkinson.
1997: Pramipexole tau pom zoo rau kev siv tshuaj hauv Tebchaws Meskas raws li kev kho mob rau Parkinson's disease.
2006: Pramipexole kuj tau txais kev pom zoo rau kev kho mob ntawm ob txhais ceg tsis xis nyob. Nws tuaj yeem siv los tswj cov tsos mob ntawm ob qho tib si Parkinson tus kab mob thiab cov ceg tsis muaj zog, tshwj xeeb tshaj yog rau cov menyuam yaus thiab cov tub ntxhais hluas.
2016: Pramipexole tau tshwm sim raws li cov khoom muaj nyob hauv ob qho tshuaj sib cais, pom zoo los ntawm US FDA. Qhov no txhais tau hais tias Pramipexole tuaj yeem siv los ua cov khoom lag luam ib leeg lossis ua ke nrog lwm cov tshuaj.
Nws raws li hydrochloride ntsev dihydrate daim ntawv ntawm Pramipexole, txhim kho cov tshuaj solubility thiab stability nyob rau hauv formulations. Qhov no pab kom tswj tau cov koob tshuaj zoo dua thiab txhim kho cov txiaj ntsig kho.
Sij hawm dhau mus, Pramipexole thiab nws daim ntawv hydrochloride ntsev dihydrate tau maj mam dhau los ua ib qho kev kho mob tseem ceeb rau cov neeg mob Parkinson tus kab mob thiab cov ceg tsis so.
Cov ntaub ntawv tseem ceeb:
|
Khoom npe |
Pramipexole 2HCL monohydrate |
|
Lwm lub npe |
Pramipexole HCL |
|
CAS |
191217-81-9 |
|
MF |
C10H20ClN3OS |
|
MW |
265.8 |
|
EINECS |
687-708-9 |
|
MDL Nr. |
ib 00876894 |
|
Purity |
99% |
|
Kev ruaj ntseg |
ruaj khov |
|
Daim ntawv thov |
Qib Tshuaj & Kev Tshawb Fawb Qib. |
|
Ntim |
Raws li koj qhov kev thov |
|
Cia |
Chav ntsuas kub. |
|
Cov qauv qauv |
|
Cov qauv zoo:
|
Cov khoom |
Specifications |
Cov txiaj ntsig |
|
Qhov tshwm sim |
Dawb los yog yuav luag dawb crystalline hmoov |
Dawb crystalline hmoov |
|
Solubility |
Dawb soluble hauv dej, soluble hauv methanol, me ntsis soluble hauv ethanol thiab xyaum insoluble hauv dichloromethane |
Ua raws |
|
Kev txheeb xyuas |
kev sib hloov kho qhov muag IR Enantiometric impurity D tsis ntau tshaj 0.5% Nws muab cov tshuaj chloride |
Ua raws |
|
Qhov tshwm sim ntawm kev daws teeb meem |
Tsis muaj xim ntau dua li kev siv tshuaj Y6 |
Ua raws |
|
Kev sib hloov kho qhov muag tshwj xeeb |
{{0}} degree --69.5 degree (C=1.0, methanol) |
68.2 degree |
|
pH |
2.8~3.4 |
3.00 |
|
Cov khoom muaj feem xyuam impurity A Impurity B Cov impurity C Tej yam tsis meej tsis meej Tag nrho impurity |
Tsawg dua lossis sib npaug rau 0.15% Tsawg dua lossis sib npaug rau 0.15% Tsawg dua lossis sib npaug rau 0.15% Tsawg dua lossis sib npaug rau 0.10% Tsawg dua lossis sib npaug rau 0.50% |
0.114% Tsis pom Tsis pom Tsis pom 0.114% |
|
Enantiomeric |
Tsawg dua lossis sib npaug rau 0.50% |
0.05% |
|
Cov hlau hnyav |
Tsawg dua lossis sib npaug li 10ppm |
< 10ppm |
|
Dej (KF) |
4.5%-6.5% |
5.96% |
|
Sulfated tshauv |
Tsawg dua lossis sib npaug rau 0.1% |
0.04% |
|
Assay (anhydrous khoom) |
99.0%~101.0% |
100.0% |
|
Txwv rau residual kuab tshuaj Acetone Ethanol Chloroform Ethyl acetate hmoov Tetrahydrofıran |
Tsawg dua lossis sib npaug li 5000ppm Tsawg dua lossis sib npaug li 5000ppm Tsawg dua lossis sib npaug li 60ppm Tsawg dua lossis sib npaug li 5000ppm Tsawg dua lossis sib npaug li 5000ppm |
Tsis pom 192ppm ua Tsis pom 80ppm ua Tsis pom |
|
Xaus |
Analysis raws li EP |
|
Tsuas yog siv rau kev lag luam lossis kev tshawb fawb, tsis yog khoom siv rau ib tus neeg twg!
Kev ruaj ntseg:
Pramipexole dihydrochloride monohydrateyog ib qho uas nquag siv dopamine receptor agonist. Nws ruaj khov nyob ntawm ntau yam, suav nrog kev cia khoom thiab kev tsim qauv. Feem ntau hais lus, thaum khaws cia kom zoo, nws ruaj khov.
Kub: nws yuav tsum tau muab cia rau hauv chav tsev kub. Tsis txhob raug rau qhov kub siab heev lossis qis qis vim nws tuaj yeem cuam tshuam rau kev ruaj ntseg ntawm cov khoom sib xyaw.
Humidity: Lub xub ntiag ntawm cov av noo tuaj yeem cuam tshuam nws txoj kev ruaj ntseg. Nws yog ib qho tseem ceeb los tiv thaiv cov tshuaj los ntawm cov dej noo ntau dhau vim nws tuaj yeem ua rau degradation. Xyuas kom meej tias lub thawv ntim tau raug kaw kom tsis txhob ya raws nkag mus.
Lub teeb: nws yuav tsum tau tiv thaiv los ntawm tshav ntuj ncaj qha. Ntev ntev raug rau lub hnub ncaj qha los yog cov khoom siv hluav taws xob tuaj yeem ua rau muaj kev puas tsuaj. Khaws cov tshuaj rau hauv nws lub thawv opaque qub lossis khaws cia rau hauv lub thawv uas tsis muaj teeb meem.
Cia:
Cov xwm txheej khaws cia yog raws li nram no:
Kub: Khaws nws ntawm chav tsev kub. Tsis txhob raug rau qhov kub thiab txias heev.
Humidity: nws los ntawm cov av noo ntau dhau los ntawm kev ua kom lub thawv ntim nruj kom tiv thaiv kom tsis txhob ya raws. Nws yog qhov zoo tshaj rau khaws cov tshuaj nyob rau hauv ib qho chaw uas tsis tshua muaj txheeb ze humidity.
Lub teeb: Tsis txhob raug tshav ntuj ncaj qha rau nws. Ntev ntev raug rau lub hnub ncaj qha los yog cov khoom siv teeb pom kev zoo tuaj yeem ua rau muaj kev puas tsuaj. Khaws cov tshuaj rau hauv nws lub thawv opaque qub lossis siv lub thawv uas tsis muaj teeb meem.
Ntim: Khaws cia rau hauv nws qhov ntim thawj, uas feem ntau yog tsim los muab kev ruaj ntseg thiab kev tiv thaiv zoo.
Cia qhov chaw: Khaws rau hauv qhov chaw qhuav, huv si, tiv thaiv lub teeb, thiab qhov cua zoo. Tsis txhob khaws cia rau hauv qhov chaw ntub dej lossis qhov chaw ntub dej, thiab tsis txhob muab tso rau hauv qhov chaw xws li chav ua noj lossis chav dej.
Packing & shipping
Ntim:
|
1 ~ 2 kg |
|
|
2-10kg |
|
|
10-25kg |
|
Shipping:
|
Tsawg dua los yog sib npaug li 50 kg |
Los ntawm kev nthuav qhia qhov rooj rau qhov rooj Fedex, DHL, UPS, TNT, EMS thiab lwm yam. Ceev thiab yooj yim |
|
|
50kg-200kg |
Los ntawm huab cua Ceev thiab pheej yig |
|
|
Ntau tshaj lossis sib npaug li 200kg |
Los ntawm hiav txwv Txoj kev pheej yig tshaj |
|
|
Los yog raws li koj yuav tsum tau xaiv txoj kev pheej yig tshaj los yog ceev.
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