Khoom Description
Posaconazole yog dab tsi?
Posaconazole hmoovyog chemical raw khoom. Nws cov mis molecular yog C37H42F2N8O4, nws cov txheeb ze molecular loj yog 700.8 g / mol, thiab nws tus lej CAS yog171228-49-2.
Nws cov qauv tshuaj muaj xws li ntau yam qauv xws li lub nplhaib triazole, benzofuran nplhaib, lub nplhaib uas muaj ntxhiab, oxime, thiab carboxylic acid. Cov molecule muaj stereoisomers feem ntau tshwm sim los ntawm ob lub chaw chiral. Nws yog cov hmoov dawb los yog yuav luag dawb. Nws yog insoluble hauv dej, soluble hauv ethanol, acetone, dichloromethane thiab methanol.
Tom qab kev tswj hwm qhov ncauj lossis tso dej,Posaconazole APIua rau cov metabolism hauv lub siab los tsim cov metabolites uas muaj zog tiv thaiv kab mob. Cov khoom lag luam metabolic ntawm cov tshuaj feem ntau yog tawm los ntawm ob lub raum, thiab ib nrab tawm los ntawm daim siab thiab cov kua tsib ducts.
Nws yog ib tug dav-spectrum antifungal tshuaj uas exerts nws fungicidal nyhuv los ntawm kev cuam tshuam nrog lub synthesis ntawm fungal cell phab ntsa thiab daim nyias nyias. Nws muaj kev ua haujlwm zoo ntawm cov kab mob fungicidal tawm tsam ntau yam kab mob thiab tau dav siv los kho cov kab mob fungal xws li qhov ncauj candidiasis, pulmonary aspergillosis, cryptococcosis, thiab mucormycosis.
Nws tau tsim los ntawm Pfizer. Hauv qab no yog nws keeb kwm kev loj hlob:
Xyoo 1998, Pfizer pib tsim nws.
Hauv xyoo 2003, nws nkag mus rau theem kev sim tshuaj.
Nyob rau hauv 2006, nws tau pom zoo los ntawm FDA rau qhov ncauj ncua kev kawm ntawv rau kev kho mob ntawm refractory fungal kab mob.
Hauv xyoo 2013, nws tau pom zoo los ntawm European Medicines Agency (EMA) los kho cov kab mob uas tsis muaj txiaj ntsig lossis ua tsis taus rau lwm cov tshuaj tiv thaiv kab mob, suav nrog aspergillosis, kab mob candida thiab Cryptococcosis.
Hauv xyoo 2014, nws tau pom zoo los ntawm FDA.
Nws tau dhau los ntawm ntau qhov kev sim tshuaj, suav nrog kev sim kho rau pulmonary aspergillosis, Cryptococcosis, mycoplasma pneumonia thiab lwm yam kab mob. Nyob rau hauv cov kev sim tshuaj no, nws tau pom zoo antifungal kev ua si thiab kam rau ua. Nws tau dhau los ua ib qho ntawm cov tshuaj tseem ceeb rau kev kho cov kab mob refractory fungal thiab tiv thaiv kab mob.
Cov ntaub ntawv tseem ceeb:
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Khoom npe |
Posaconazole |
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Lwm lub npe |
4-{4-[4-(4-{[(3R,5R)-5-(2,4-difluorophenyl)tetrahydro{{9} }(1H-1,2,4-triazol-1-ylmethyl)-3-furylmethoxy]phenyl)piperazin-1-yl]phenyl}-2-[( 2S,3S)-2-hydroxypentan-3-yl]-2,4-dihydroxypyrimidine-5-carboxylic acid |
|
CAS |
171228-49-2 |
|
MF |
C37H42F2N8O4 |
|
MW |
700.78 |
|
EINECS |
682-747-8 |
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MDL Nr. |
TIAB SA 00941162 |
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Purity |
99% |
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Kev ruaj ntseg |
ruaj khov thaum khaws cia rau hauv cov xwm txheej tsim nyog. |
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solubility |
Me ntsis soluble hauv dej |
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Daim ntawv thov |
Qib tshuaj los yog siv rau kev tshawb fawb. |
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Ntim |
Raws li koj qhov kev thov |
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Cia |
Chav ntsuas kub. |
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Cov qauv qauv |
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Cov qauv zoo:
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Yam khoom |
Specification |
Cov txiaj ntsig |
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Qhov tshwm sim |
Tawm-dawb mus rau dawb hmoov |
Ua raws |
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Solubility |
Soluble hauv dichloromethane thiab xyaum insoluble hauv dej |
Ua raws |
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Kev txheeb xyuas |
IR Lub infrared absorption spectrum ntawm tus qauv yuav tsum concordant nrog posaconazole (form -1) tus qauv spectrum |
Ua raws |
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HPLC Lub sijhawm khaws cia ntawm lub ncov loj hauv chromatogram ntawm cov qauv sib raug rau qhov hauv chromatogram ntawm tus qauv npaj |
Ua raws |
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Kev sib hloov tshwj xeeb |
-24.5 degree rau -28.5 degree (anhydrous hauv paus) (C=1, hauv acetone) |
-26.6. degree |
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Kev ntsuam xyuas los ntawm HPLC |
98% -102% (anhydrous hauv paus) |
98.8% |
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Cov tshuaj sib txuas |
Tosylated compound NMT0.1% |
N.D |
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Hydroxy triazole NMT 0.1% |
N.D |
|
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Benzylated posaconazole NMT 0.1% |
0.07% |
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Ib qho impurities NMT 0.2% |
0.17% |
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Tag nrho impurities NMT1.0% |
0.38% |
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SSRR isomer NMT0.1% |
N.D |
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Chiral purity los ntawm HPLC |
RRRS isomer NMT0.1% |
N.D |
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RRRR isomer NMT0.1% |
N.D |
|
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Tatal isomer NMT1.0% |
0.014% |
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Cov ntsiab lus dej (KF) |
NMT1.0% |
0.18% |
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Hnyav Hlau |
NMT 10 ppm |
Ua raws |
|
Poob rau ziab |
NMT 0.5% |
0.01% |
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Xaus |
Cov khoom kuaj tau ua raws li qhov tshwj xeeb |
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Tsuas yog siv rau kev lag luam lossis kev tshawb fawb, tsis yog khoom siv rau ib tus neeg twg!
Kev ruaj ntseg & Cia
Posaconazolehmoovyog ib yam khoom ruaj khov nrog zoo thermal stability thiab lub teeb ruaj khov, uas tuaj yeem khaws cia rau ntau xyoo nyob rau hauv ib txwm khaws cia. Nws yog qhov ruaj khov nyob rau hauv acidic tej yam kev mob, tab sis tsis ruaj khov nyob rau hauv alkaline tej yam kev mob. Nws yuav raug degradation inalkaline tej yam kev mob. Tsis tas li ntawd, nws kuj tsis ruaj khov hauv dej. yog li nws yuav tsum tau zam los ntawm kev raug dej ncaj qha los yog qhov chaw muaj av noo siab. Thaum cov txheej txheem npaj, yuav tsum tau saib xyuas kom tsis txhob muaj kev sib cuag nrog cov khoom xws li oxidants, txo cov neeg ua haujlwm thiab cov hlau ions kom tsis txhob cuam tshuam rau nws txoj kev ruaj ntseg. Ua ntej siv, ua tib zoo xyuas lub khw thiab siv raws li cov lus qhia kom paub tseeb tias nws zoo thiab ua haujlwm zoo.
Cov xwm txheej khaws cia yuav tsum ua raws li cov cai hauv qab no:
Kub: Nws yuav tsum tau khaws cia rau hauv ib puag ncig ntawm 15-30 degrees Celsius, tsis txhob kub dhau los yog qis, thaum tseem tiv thaiv kev raug UV hluav taws xob ncaj qha.
Humidity: Nws yuav tsum muab cia rau hauv qhov chaw qhuav thiab qhov cua, tsis txhob dampness thiab high humidity ib puag ncig.
Ntim: Nws yuav tsum tau muab khaws cia kom nruj, khaws lub ntim kom zoo thiab tsis muaj kev puas tsuaj.
Lwm yam: Thaum khaws cia, tsis txhob sib cuag nrog oxidants, reducers, hlau ions, thiab lwm yam khoom los tiv thaiv cov tshuaj tsis tsim nyog thiab cuam tshuam rau qhov zoo thiab kev ua tau zoo ntawm cov tshuaj.
Hauv cov ntsiab lus, thaum khaws cia, yuav tsum tau saib xyuas kom tsis txhob muaj kev cuam tshuam ntawm huab cua kub, av noo thiab lwm yam ib puag ncig kom ntseeg tau tias nws zoo thiab ruaj khov.
Packing & shipping
Ntim:
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1 ~ 2 kg |
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2-10kg |
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|
10-25kg |
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Shipping:
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Tsawg dua los yog sib npaug li 50 kg |
Los ntawm kev nthuav qhia qhov rooj rau qhov rooj Fedex, DHL, UPS, TNT, EMS thiab lwm yam. Ceev thiab yooj yim |
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50kg-200kg |
Los ntawm huab cua Ceev thiab pheej yig |
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Ntau tshaj lossis sib npaug li 200kg |
Los ntawm hiav txwv Txoj kev pheej yig tshaj |
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Los yog raws li koj yuav tsum tau xaiv txoj kev pheej yig tshaj los yog ceev. |
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Lub sijhawm them nyiaj
Vim li cas thiaj xaiv Xi'an Yihui?
Hauv cov ntsiab lus, raws li lub Hoobkas tsim cov khoom siv tshuaj Posaconazole (API), peb ib txwm ua raws li lub hauv paus ntsiab lus ntawm kev ua tau zoo ua ntej, xyuas kom meej tias cov txheej txheem tsim ua raws li cov kev cai thiab cov qauv. peb ua ib tug series ntawm kev ntsuas los xyuas kom meej stability, siab purity, thiab tsis muaj impurities ntawm lubPosaconazole hmoov, yog li muab cov khoom zoo tshaj plaws rau cov neeg siv khoom.
Xi 'an Yihui tuam txhab muag khoom, khoom siv ntau lawm
Xi'an Yihui tuam txhab muaj qib siab ntawm kev tshawb fawb thiab kev txhim kho muaj peev xwm
Xi 'an Yihui Company's Advanced ntau lawm cov cuab yeej thiab tshuab
Zoo meej kev pab cuam tom qab muag
Cim npe nrov: Tuam Tshoj posaconazole hmoov manufacturers, lwm tus neeg, Hoobkas
