Docetaxel hmoov

Docetaxel yog dab tsi?

Docetaxel hmoovyog ib tug taxoid-chav kawm derivative ntawm paclitaxel, uas yog muab rho tawm los ntawm cov tawv ntoo ntawm tsob ntoo yew. Nws yog dej-insoluble dawb mus rau daj daj crystalline hmoov nrog ib tug molecular mis ntawm C43H53NO14 thiab ib tug txheeb ze molecular loj ntawm 807.88 g / mol. Nws lub npe tshuaj yog (2 ,3 ,5 ,7 ,10 ,13 )-4-acetoxy-13-({(2R,3S)-3-[(tert-butoxycarbonyl)amino]-2-hydroxy-3-phenylpropanoyl}oxy){2}{2}{2}hydroxy,2} ,20-epoxytax-11-en-2-yl benzoate, thiab nws tus lej CAS yog114977-28-5.

Cov txheej txheem ntau lawm ntawmDocetaxel APIFeem ntau suav nrog cov kauj ruam hauv qab no:

Extract nws precursor los ntawm paclitaxel

Ua ntej, paclitaxel yog tshuaj hloov mus rau hauv 10-deacetylbaccatin III precursor. Cov txheej txheem no feem ntau xav tau cov kuab tshuaj thiab cov catalysts.

Synthesis

Tom qab ntawd, 1, 2-di-phenyl-1-thioacetoxyethane (DTE) yog siv los ua ib qho nruab nrab rau tag nrho cov synthesis ntawm Docetaxel. Yuav tsum muaj cov tshuaj lom neeg cov tshuaj tiv thaiv kab mob hauv cov txheej txheem no, thiab alkaline catalysts yog siv los pab cov tshuaj tiv thaiv.

Purification thiab crystallization

Tom qab cov tshuaj tiv thaiv, cov khoom yuav tsum tau purified thiab crystallized kom tau siab purity thiab zoo crystallinity Docetaxel crystals. Cov kuab tshuaj xws li isopropanol tuaj yeem siv rau kev rho tawm thiab ua kom huv thaum lub sijhawm ua haujlwm no.

Sib tsoo thiab kuaj

Cov khoom siv lead ua yuav tsum tau txais kev sib tsoo thiab kev sim zoo los tsim cov khoom kawg uas ua tau raws li tus qauv.

Tag nrho cov txheej txheem tsim khoom yuav tsum muaj kev ua haujlwm nruj thiab kev tswj xyuas kom zoo los xyuas kom meej tias cov khoom tsim tau ua tau raws li cov qauv tshuaj zoo thiab tuaj yeem siv nyab xeeb thiab siv tau zoo hauv kev kho mob qog noj ntshav.

Cov ntaub ntawv tseem ceeb:

Cov qauv zoo:

Tsuas yog siv rau kev lag luam lossis kev tshawb fawb, tsis yog khoom siv rau ib tus neeg twg!

Kev ruaj ntseg & Cia

Rau Stability,Docetaxel hmoovyuav tsum tau khaws cia rau hauv qhov qhuav, txias, tsaus, thiab kaw lub thawv kom tsis txhob ya raws thiab lub teeb-mediated decomposition. Nws yuav tsum tau khaws cia kom deb ntawm qhov kub thiab txias, high humidity, thiab nplaim taws qhov chaw. Feem ntau, nws yuav tsum khaws cia ntawm qhov kub thiab txias -20 degree lossis qis dua. Yog tias yuav tsum tau khaws cia ntev ntev, kev siv cov pa oxygen scavengers thiab inert gases tuaj yeem pab tiv thaiv nws txoj kev ruaj ntseg.

Rau kev siv, nws yuav tsum tau diluted thiab npaj rau hauv cov kuab tshuaj uas tsim nyog thiab siv sai li sai tau tom qab kev npaj. Thaum tov nrog lwm yam tshuaj, nws compatibility yuav tsum tau ua tib zoo xav. Nws cov tshuaj txhaj tshuaj yuav tsum tau siv tam sim tom qab kev npaj thiab yuav tsum tsis txhob tov nrog lossis ntxiv rau lwm yam tshuaj. Nws txoj kev ruaj ntseg kuj yuav tsum tau khaws cia thaum siv, xws li tsis txhob raug tshav ntuj, tsis txhob co los yog muaj zog vibration.

Zuag qhia tag nrho, kev tswj hwm ib puag ncig yog tsim nyog los xyuas kom meej tias nws ruaj khov thiab ua haujlwm tau zoo thaum khaws cia thiab siv. Nws yuav tsum tau siv raws li cov txheej txheem kho mob thiab cov kws kho mob cov lus pom zoo kom lav nws cov txiaj ntsig kho mob.

Nws yuav tsum tau muab khaws cia rau hauv cov xwm txheej tshwj xeeb kom ntseeg tau tias nws ruaj khov thiab ua haujlwm tau zoo. Feem ntau, cov hauv qab no yog cov txheej txheem khaws cia:

Kub: Nws yuav tsum tau khaws cia ntawm qhov kub thiab txias hauv -20 degree lossis qis dua kom tsis txhob muaj qhov kub thiab txias. Thaum lub sij hawm npaj, cov tshuaj npaj yuav tsum tau muab tso rau hauv lub tub yees uas tsis muaj kub los yog lub freezer rau khaws cia.

Humidity: Nws yuav tsum muab cia rau hauv qhov chaw qhuav kom tsis txhob ya raws lossis khov. Yog li ntawd, qhov chaw cia yuav tsum qhuav li sai tau, thiab cov cuab yeej pabcuam xws li dehumidifiers tuaj yeem txiav txim siab.

Kev zam lub teeb: Nws yuav tsum tau khaws cia kom deb ntawm lub hnub ncaj qha los yog lub teeb pom kev zoo kom tiv thaiv kom tsis txhob decomposition lossis degradation. Yog li ntawd, qhov chaw cia yuav tsum muaj qhov cua zoo, thiab cov ntaub thaiv npog los yog cov txee tuaj yeem siv los tiv thaiv.

Ntim: Nws yuav tsum tau muab khaws cia rau hauv lub khob kaw los yog lub raj mis polyethylene, kom ntseeg tau tias lub raj mis sealing zoo. Ua ntej siv, nws yuav tsum tau kuaj xyuas tias lub raj mis puas lawm, thiab lub raj mis qhib lossis puas yuav tsum tsis txhob siv.

Hauv cov ntsiab lus, kom ntseeg tau tias nws qhov kev ruaj ntseg zoo thiab sib xws, nws yog ib qho tsim nyog yuav tsum ua raws li cov xwm txheej saum toj no thaum khaws cia thiab siv. Yog tias yuav tsum tau khaws cia ntev, kev siv cov pa oxygen scavengers thiab inert gases tuaj yeem raug txiav txim siab, thiab kev kuaj xyuas tsis tu ncua yuav tsum tau ua kom ntseeg tau tias nws ua tau zoo thiab kev nyab xeeb.

Ntim:

Shipping:

Raws li ib tugDocetaxel hmoovHoobkas, peb yuav muab peb cov neeg muas zaub cov khoom zoo. Peb yuav tsim kom muaj kev pabcuam tiav, muab kev pabcuam tshwjxeeb thiab kev pabcuam tomqab muag, thiab ua txhua yam los txhim kho cov neeg siv khoom txaus siab.

Xi 'an Yihui tuam txhab muag khoom, khoom siv ntau lawm

Xi'an Yihui tuam txhab muaj qib siab ntawm kev tshawb fawb thiab kev txhim kho muaj peev xwm

Xi 'an Yihui Company's Advanced ntau lawm cov cuab yeej thiab tshuab

Zoo meej kev pab cuam tom qab muag

Cim npe nrov: Tuam Tshoj docetaxel hmoov manufacturers, lwm tus neeg, Hoobkas