Khoom Description

Mitomycin C yog dab tsi?

Mitomycin C hmoovyog ib tug natural tshuaj tua kab mob analog. nws lub npe tshuaj yog (6S)-6-amino-4,7,8,9-tetrahydronaphtho[2,3-c]quinoline-5,{{9} }dione. Nws cov qauv molecular yog C15H18N4O5. Nws Formula Luj yog 334.33. CAS No50-07-7. Nws yog xiav crystalline hmoov nrog muaj zog cytotoxicity. Nws cov qauv muaj lub nplhaib uas muaj ntxhiab thiab muaj tsib-tus tswv cuab heterocycle, thiab nyob rau hauv cov xwm txheej ntawm lub cev, nws tuaj yeem ua rau ib qho kev hloov hluav taws xob hloov mus rau crosslink nrog DNA, yog li inhibiting DNA synthesis thiab cell division, thiab ua rau cov nyhuv tuag ntawm cov hlwb.

Nws tau raug cais los ntawm cov kws tshawb fawb Nyij Pooj Hata thiab Umezawa los ntawm cov kab mob hu ua Streptomyces caespitosus hauv xyoo 1956. Thaum lub sijhawm ntawd, lawv tau ua cov txheej txheem ntawm kev rho tawm thiab kev ua kom zoo ntawm cov kab lis kev cai nruab nrab ntawm Streptomyces caespitosus, thiab nws thiaj li nrhiav tau Mitomycin C.

Nyob rau tib lub sijhawm, kev tshawb fawb ntau thiab ntau tau pom tias nws yog ib qho kev sib xyaw nrog cov teebmeem dav dav. Nws kuj yog siv nyob rau hauv kev kho mob teb xws li phais ophthalmic thiab phais urological.

Nrog rau txoj kev loj hlob ntawm biotechnology, tib neeg pib tshawb nrhiav kom muaj kev nyab xeeb thiab muaj txiaj ntsig zoo dua Mitomycin C derivatives los txhim kho lawv cov kev kho mob thiab cov kev mob tshwm sim. Txog tam sim no, qee cov derivatives xws li Mitomycin B, Mitomycin A, Aziridinomitosen tau tsim, thiab cov Mitomycin C derivatives tshiab txuas ntxiv mus.

Cov ntaub ntawv tseem ceeb:

Khoom npe	Mitomycin C
Tshuaj npe	(6S)-6-amino-4,7,8,9-tetrahydronaphtho[2,{7}}c]quinoline-5,10-dione
CAS	50-07-7
MF	C15H18N4O5
MW	334.33
EINECS	50-07-7
MDL Nr.	PAB 00078109
Purity	99%
Kev ruaj ntseg	ruaj khov
Daim ntawv thov	Qib tshawb fawb.
Ntim	Raws li koj qhov kev thov
Cia	Lub tub yees
Tus qauv qauv:

Cov qauv zoo:

Cov khoom	Specification	Cov txiaj ntsig
Qhov tshwm sim	Blue-violet crystals los yog crystalline hmoov.	Blue-violet crystalline hmoov
Kev txheeb xyuas	IR: Sib piv: mitomycin CRS	Ua raws
	HPLC: Lub sijhawm khaws cia ntawm lub ncov loj ntawm cov qauv kev daws teeb meem sib raug rau cov qauv kev daws teeb meem, raws li tau txais hauv Kev Tshawb Fawb.	Ua raws
Crystallinity	Crystals los yog crystalline hmoov	Crystalline hmoov
pH	6.0-7.5	6.6
Dej	Tsawg dua lossis sib npaug li 2.5%	0.1%
Cov khoom muaj feem xyuam	Albomitomycin C Tsawg dua lossis sib npaug rau 0.5%	＜0.1%
	Mitomycin B Tsawg dua lossis sib npaug rau 0.5%	ND
	Cinnamamide Tsawg dua lossis sib npaug rau 0.5%	＜0.1%
	Mitomycin A Tsawg dua lossis sib npaug rau 0.5%	ND
	Ib tus neeg twg uas tsis qhia meej impurity Tsawg dua lossis sib npaug rau 0.5%	＜0.1%
	Tag nrho cov impurities Tsawg dua lossis sib npaug rau 2.0%	＜0.1%
Residual kuab tshuaj	Methanol Tsawg dua lossis sib npaug li 3000 ppm	3000 ppm
	Ethyl ether Tsawg dua los yog sib npaug rau 5000 ppm	± 5000 ppm
	Ethyl acetate Tsawg dua lossis sib npaug li 5000 ppm	± 5000 ppm
Assay	Ntau dua lossis sib npaug li 970 ug / mg	1003 ug/mg
Kev kuaj tsis muaj menyuam	---	Tsis muaj menyuam
Kev kuaj kab mob endotoxins	Tsawg dua lossis sib npaug rau 10.0 USP Endotoxin Units/mg ntawm mitomycin	Ua raws
Xaus	Ua raws li USP

Tsuas yog siv rau kev lag luam lossis kev tshawb fawb, tsis yog khoom siv rau ib tus neeg twg!

Kev ruaj ntseg: Mitomycin C hmoovyog tsis ruaj tsis khov thiab yooj yim decomposed los ntawm tej yam xws li lub teeb, tshav kub, acid, thiab alkali. Nws ib nrab-lub neej nyob rau hauv kev daws yog luv luv, tsuas yog ob peb teev rau ib hnub. Yog li ntawd, kev tiv thaiv kev sib raug zoo yuav tsum tau ua thaum lub sijhawm tsim khoom, khaws cia, thiab siv, xws li tsis txhob raug tshav ntuj ncaj qha, khaws cia rau hauv qhov chaw qhuav thiab txias, thiab tsis txhob cuam tshuam nrog acids thiab alkalis, kom ntseeg tau tias muaj kev ntseeg siab thiab sib xws ntawm nws cov tshuaj pharmacological. Tsis tas li ntawd, nws cov derivatives, xws li Mitomycin B, muaj kev ruaj ntseg zoo dua thiab tuaj yeem ua tau raws li qhov xav tau ntawm kev siv tshuaj.

Solubility:Nws solubility yog tsawg. Nws solubility hauv dej yog li 1.32 mg / mL. Nws kuj tuaj yeem yaj hauv methanol, ethanol, chloroform, thiab dimethyl sulfoxide. Thaum khaws cia thiab siv nws, cov kuab tshuaj ntau dhau yuav tsum tau zam kom tsis txhob muaj kev cuam tshuam rau nws cov kev ua haujlwm lom neeg. Nyob rau tib lub sijhawm, nws qhov ruaj khov yuav tsum tau sau tseg vim tias nws yooj yim decomposed hauv kev daws teeb meem los ntawm lub teeb, cua sov, acid, alkali, thiab lwm yam.

Cia:Cov ntsiab lus hauv qab no yuav tsum tau sau tseg thaum khaws cia:

Khaws qhov kub thiab txias: Nws yuav tsum muab cia rau hauv qhov chaw qhuav thiab txias, tsis txhob tshav ntuj ncaj qha thiab kub siab, thiab qhov kub zoo tshaj plaws yog -20 degree .

Vim hais tias nws yog rhiab heev rau lub teeb, nws yog ib qho tsim nyog yuav tsum tsis txhob muaj lub teeb thaum lub sij hawm cia thiab qhwv nws nyob rau hauv aluminium ntawv ci los yog lub teeb thaiv lub hnab.

Tsis txhob ya raws: Nws muaj hygroscopicity thiab yuav tsum tau muab tso rau hauv lub thawv kaw nrog lub desiccant kom nws lub xeev qhuav.

Tiv thaiv kev vibration: Thaum lub sij hawm thauj mus los thiab lwm yam txheej txheem, nws yuav tsum tau tiv thaiv los ntawm kev sib tsoo los yog sib tsoo nrog lwm yam khoom kom tswj tau nws txoj kev ncaj ncees.

Feem ntau hais lus, nws yuav tsum tau ua raws li cov hauv paus ntsiab lus ntawm qhov kub thiab txias, kev zam lub teeb, tiv thaiv kom tsis txhob ya raws, thiab tiv thaiv kev poob siab thaum khaws cia. Ua ntej siv, nws cov tsos, solubility, thiab pharmacological teebmeem yuav tsum tau kuaj xyuas. Yog tias muaj cov xwm txheej txawv txav xws li crystallization, hloov xim, txo solubility, lossis txo kev ua haujlwm, nws yuav tsum tau nres thiab cov lus qhia kev tshaj lij yuav tsum tau nrhiav.

Packing & shipping

Ntim:

1 ~ 2 kg
2-10kg
10-25kg

Shipping:

Tsawg dua los yog sib npaug li 50 kg	Los ntawm kev nthuav qhia qhov rooj rau qhov rooj Fedex, DHL, UPS, TNT, EMS thiab lwm yam. Ceev thiab yooj yim
50kg-200kg	Los ntawm huab cua Ceev thiab pheej yig
Ntau tshaj lossis sib npaug li 200kg	Los ntawm hiav txwv Txoj kev pheej yig tshaj
Los yog raws li koj yuav tsum tau xaiv txoj kev pheej yig tshaj los yog ceev.