Khoom Description
Tacrolimus yog dab tsi?
Tacrolimus hmoov, tseem hu ua FK506, yog ib hom macrocyclic lactone compound nrog cov qauv molecular ntawm C44H69NO12 thiab cov txheeb ze molecular loj ntawm 804.02 g / mol. Nws tus lej CAS yog104987-11-3. nws cov qauv tshuaj muaj ib tug 23-membered macrocycle thiab ob rotatable alkyl sab chains. Cov qauv tshwj xeeb no muab nws lub zog tiv thaiv kab mob, ua rau nws yog ib qho tseem ceeb los tiv thaiv cov tshuaj tiv thaiv.
Tacrolimus APIyog ib qho tshuaj tiv thaiv kab mob, uas feem ntau yog siv los tiv thaiv thiab kho kev tsis lees paub tom qab hloov khoom nruab nrog cev. Nov yog qhov qhia txog nws keeb kwm kev loj hlob:
Discovery: nws tau pib tsim los ntawm Kobayashi Pharmaceutical Co., ib lub tuam txhab Nyij Pooj, thiab tau raug cais tawm thawj zaug hauv xyoo 1984. Cov kws tshawb fawb tau cais Tacrolimus los ntawm cov qauv av ntawm cov kab mob hu ua Streptomyces tsukubaensis.
Daim ntawv thov kev kho mob: Hauv xyoo 1994, nws tau txais kev pom zoo los ntawm US Food and Drug Administration ua tshuaj rau kev tiv thaiv kab mob tom qab hloov khoom nruab nrog cev.
Kev nthuav dav ntawm daim ntawv thov teb: Lub sijhawm dhau los, nws daim ntawv thov tau nthuav dav.
Formulation txhim kho: Thaum xub thawj, nws muaj nyob rau hauv daim ntawv capsule.
Kev ua kom zoo ntawm cov txheej txheem synthesis: Ntxiv rau kev rho tawm los ntawm cov khoom siv ntuj tsim, cov kws tshawb fawb tau txhim kho cov txheej txheem synthesis kom ua tiav ntau dua thiab ruaj khov. Cov kev tsim kho tshiab no pab txhim kho nws txoj kev nkag tau yooj yim thiab kev tswj kom zoo.
Feem ntau, raws li ib qho tseem ceeb Immunosuppressive tshuaj, nws plays lub luag hauj lwm tseem ceeb nyob rau hauv kev kho mob ntawm lub cev hloov thiab lwm yam kev tiv thaiv kab mob. Nyob rau tib lub sijhawm, nws daim ntawv thov thiab kev tsim qauv tau hloov zuj zus, thiab kev nce qib hauv cov txheej txheem synthesis tau ua, ua rau muaj txiaj ntsig zoo rau cov neeg mob.
Cov ntaub ntawv tseem ceeb:
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Khoom npe |
Tacrolimus |
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tshuaj npe |
(3S,4R,5S,8R,9E,12S,14S,15R,16S,18R,19R,26aS)-5,19-dihydroxy-3-{(1E){16} [(1R,3R,4R)-4-hydroxy-3-methoxycyclohexyl]prop-1-en-2-yl}-14,16-dimethoxy{{ 26},10,12,18-tetramethyl-8-(prop-2-en{32}}yl)-5,6,8,11,12,13, 14,15,16,17,18,19,24,25,26,26a-hexadecahydro-3H-15,19-epoxypyrido[2,{54}}c][ 1,4]oxazacyclotricosine-1,7,20,21(4H,23H)-tetrone. |
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CAS |
104987-11-3 |
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MF |
C44 H69 N O12 |
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MW |
804.02 |
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EINECS |
1308068-626-2 |
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MDL Nr. |
ib 00869853 |
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Purity |
99% |
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Kev ruaj ntseg |
ruaj khov thaum khaws cia rau hauv cov xwm txheej tsim nyog. Nws yuav tsum tau tiv thaiv los ntawm lub teeb, noo noo, thiab kub kub. |
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solubility |
Me ntsis soluble hauv dej, soluble hauv ethanol, methanol, thiab DMSO |
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Daim ntawv thov |
Qib tshuaj los yog siv rau kev tshawb fawb. |
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Ntim |
Raws li koj qhov kev thov |
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Cia |
Chav ntsuas kub. |
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Cov qauv qauv |
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Cov qauv zoo:
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Yam khoom |
txheem |
Cov txiaj ntsig |
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Qhov tshwm sim |
Dawb crystalline hmoov. Lub sijhawm khaws cia ntawm lub ncov loj |
ua raws |
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Kev txheeb xyuas |
Kev npaj sib raug rau qhov chromatogram ntawm Standard kev npaj tau txais raws li qhia hauv Assay. |
ua raws |
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[ ]D23, hauv chloroform |
{{0}}.0 degree ~ -90 degree |
-84 degree |
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Melting Point |
125 degree ~ 129 degree |
125 degree ~ 128 degree |
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Hnyav Hlau |
Tsawg dua lossis sib npaug li 10ppm |
Ua raws |
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Lwm yam khoom siv 0.5% |
Tsawg dua lossis sib npaug rau 2.0% |
0.5% |
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Cov ntsiab lus dej (KF) |
Tsawg dua lossis sib npaug rau 3.0% |
1.8% |
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Residue ntawm ignition |
Tsawg dua lossis sib npaug rau 0.1% |
ua raws |
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Assay (ntawm qhuav hauv paus,) |
Ntau dua lossis sib npaug li 98% |
99.3% |
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Residual kuab tshuaj |
ethanol Tsawg dua lossis sib npaug li 5000ppm |
Tsis pom |
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Acetone Tsawg dua lossis sib npaug li 5000ppm |
Tsis pom |
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Kab mob |
Tsawg dua lossis sib npaug li 1000 / g |
< 10/g |
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Xaus |
Cov khoom ua raws li qhov saum toj no USP35. specifications |
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Tsuas yog siv rau kev lag luam lossis kev tshawb fawb, tsis yog khoom siv rau ib tus neeg twg!
Cov txheej txheem hluavtaws ntawmTacrolimus hmoovFeem ntau suav nrog cov kauj ruam hauv qab no:
Isoprene yog siv los ua cov khoom siv raw los tsim cov tetracyclic intermediate los ntawm sulfuric acid-catalyzed ntxiv cov tshuaj tiv thaiv.
tetracyclic intermediate yog raug rau carboxylation cov tshuaj tiv thaiv kom tau FK506 acid.
FK506 acid yog reacted nrog isohexanoyl chloride nyob rau hauv lub xub ntiag ntawm poov tshuaj carbonate los tsim FK506 precursor.
FK506 precursor dhau alkylation cov tshuaj tiv thaiv los tsim Tacrolimus.
Nws yuav tsum raug sau tseg tias ntau qhov kev sib cais zoo, kev ua kom huv, thiab cov yam ntxwv ntawm cov txheej txheem yuav tsum tau muaj nyob rau hauv cov txheej txheem synthesis, thiab kev tswj cov txheej txheem tsis tseem ceeb kuj tseem ceeb heev. Tam sim no, muaj ntau cov ntaub ntawv qhia txog kev sib txuas ntawm Tacrolimus. Txawm li cas los xij, vim nws txoj kev ua haujlwm nyuaj thiab kev ua haujlwm lom neeg, kev txhim kho txuas ntxiv thiab kev ua kom zoo dua tseem xav tau.
Tacrolimus yog dawb crystalline hmoov, uas feem ntau muaj kev ruaj ntseg zoo. Cov teeb meem ntawm kev ruaj ntseg feem ntau tsom rau yam xws li lub teeb, av noo, thiab kub.
nws yuav tsum tau zam kom tsis txhob raug lub teeb rau lub sij hawm ntev, thaum tswj kom tsim nyog cov av noo thiab kub ib puag ncig.
Packing & shipping
Ntim:
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1 ~ 2 kg |
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2-10kg |
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10-25kg |
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Shipping:
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Tsawg dua los yog sib npaug li 50 kg |
Los ntawm kev nthuav qhia qhov rooj rau qhov rooj Fedex, DHL, UPS, TNT, EMS thiab lwm yam. Ceev thiab yooj yim |
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50kg-200kg |
Los ntawm huab cua Ceev thiab pheej yig |
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Ntau tshaj lossis sib npaug li 200kg |
Los ntawm hiav txwv Txoj kev pheej yig tshaj |
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Los yog raws li koj yuav tsum tau xaiv txoj kev pheej yig tshaj los yog ceev. |
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Lub sijhawm them nyiaj
Vim li cas thiaj xaiv Xi'an Yihui?
Raws li cov kws tshaj lij kev tsim khoom ntawm Tacrolimus, peb muaj cov txiaj ntsig hauv qab no:
Cov khoom lag luam zoo: Peb ua kom zoo thiab ruaj khov ntawm peb cov khoom los ntawm kev tswj cov khoom zoo, kev siv tshuab, thiab lwm yam, uas nyiam cov neeg siv khoom ntau dua.
Lub peev xwm ruaj khov: Raws li cov chaw tsim khoom, peb tswj cov phiaj xwm tsim khoom thiab cov khoom muag kom ntseeg tau tias xa khoom raws sijhawm, ua tau raws li cov neeg siv khoom xav tau, thiab txhim kho cov neeg siv khoom txaus siab.
Cov txheej txheem ntau lawm thiab thev naus laus zis: Peb muaj cov txheej txheem ntau lawm thiab thev naus laus zis los txhim kho kev tsim khoom thiab txo cov nqi, txhim kho kev sib tw.
Pab pawg muag khoom thiab kev lag luam zoo: Peb muaj pab pawg muag khoom zoo thiab kev lag luam, peb ua haujlwm nrog cov neeg siv khoom, peb lub hom phiaj tseem ceeb yog txhim kho cov neeg siv khoom txaus siab.
Kev pab cuam tom qab muag zoo meej: Peb muab kev pabcuam zoo tshaj plaws tom qab muag, daws teebmeem sai rau cov neeg siv khoom, tsim kom muaj kev ntseeg siab thiab kev ntseeg siab, thiab txhim kho kev sib tw.
Xi 'an Yihui tuam txhab muag khoom, khoom siv ntau lawm
Xi'an Yihui tuam txhab muaj qib siab ntawm kev tshawb fawb thiab kev txhim kho muaj peev xwm
Xi 'an Yihui Company's Advanced ntau lawm cov cuab yeej thiab tshuab
Zoo meej kev pab cuam tom qab muag
Nyob rau hauv cov ntsiab lus, raws li ib tug kws Tacrolimus chaw tsim tshuaj paus, peb muaj advanced technology, scale kom zoo dua, qhov zoo tshaj plaws zoo, nplua nuj ntau lawm kev, thiab cov kev pab zoo heev. Cov txiaj ntsig zoo no yuav ua rau pebTacrolimus hmoovsawv tawm hauv kev sib tw ua lag luam thiab yeej ntau tus neeg siv khoom ntseeg siab thiab kev txhawb nqa.
Cim npe nrov: Tuam Tshoj tacrolimus hmoov manufacturers, lwm tus neeg, Hoobkas
